Cover Image

Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma

Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases associated with increased immune-surveillance may also modulate the risk of human glioma. To test this hypothesis, we used data from the well-v...

Full description

Saved in:
Bibliographic Details
Main Authors: Anssar, Tareq Marius (Author) , Leitzmann, Michael F. (Author) , Linker, Ralf A. (Author) , Meier, Christoph (Author) , Becker, Claudia (Author) , Jick, Susan (Author) , Sahm, Katharina (Author) , Platten, Michael (Author) , Hau, Peter (Author) , Seliger, Corinna (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Cancer medicine
Year: 2020, Volume: 9, Issue: 3, Pages: 1263-1275
ISSN:2045-7634
DOI:10.1002/cam4.2767
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/cam4.2767
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.2767
Get full text
Author Notes:Tareq M. Anssar, Michael F. Leitzmann, Ralf A. Linker, Christoph Meier, Claudia Becker, Susan Jick, Katharina Sahm, Michael Platten, Peter Hau, Corinna Seliger

MARC

LEADER 00000caa a2200000 c 4500
001 1694291367
003 DE-627
005 20230427094949.0
007 cr uuu---uuuuu
008 200408s2020 xx |||||o 00| ||eng c
024 7 |a 10.1002/cam4.2767  |2 doi 
035 |a (DE-627)1694291367 
035 |a (DE-599)KXP1694291367 
035 |a (OCoLC)1341314316 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Anssar, Tareq Marius  |d 1988-  |e VerfasserIn  |0 (DE-588)1113192380  |0 (DE-627)867103191  |0 (DE-576)476891590  |4 aut 
245 1 0 |a Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma  |c Tareq M. Anssar, Michael F. Leitzmann, Ralf A. Linker, Christoph Meier, Claudia Becker, Susan Jick, Katharina Sahm, Michael Platten, Peter Hau, Corinna Seliger 
264 1 |c 2020 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a First published: 10 December 2019 
500 |a Gesehen am 08.04.2020 
520 |a Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases associated with increased immune-surveillance may also modulate the risk of human glioma. To test this hypothesis, we used data from the well-validated Clinical Practice Research Datalink (CPRD) GOLD from the UK to analyze the association of immune-related disorders or use of immunosuppressive drugs and the risk of glioma. We identified 3112 incident glioma cases diagnosed between 1995 and 2017. We randomly selected up to 10 controls, matching them to glioma cases on age, sex, index date, general practice, and number of years of active history in the database prior to the index date. We performed conditional logistic regression analyses to estimate Odds Ratios (ORs) of glioma among those exposed to allergies, autoimmune diseases, and immunosuppressive drugs. Overall, we found no materially altered association between a history of any autoimmune disease (OR 0.98, 95% CI 0.86-1.11), allergy (OR 0.97, 95% CI 0.89-1.05), or use of immunosuppressive drugs and the risk of glioma. However, subgroup analyses among younger patients found a statistically significant increased risk of glioma in patients with a history of inflammatory bowel disease (IBD) (OR 2.59, 95% CI 1.31-5.12). There was also an inverse association between asthma and risk of glioma in patients with longer survival (OR 0.73, 95% CI 0.58-0.91) and between long-term duration diabetes and risk of glioma (OR 0.71, 95% CI 0.53-0.96). 
650 4 |a autoimmune diseases 
650 4 |a glioma 
650 4 |a immunosuppressive therapies 
700 1 |a Leitzmann, Michael F.  |e VerfasserIn  |4 aut 
700 1 |a Linker, Ralf A.  |e VerfasserIn  |4 aut 
700 1 |a Meier, Christoph  |e VerfasserIn  |4 aut 
700 1 |a Becker, Claudia  |e VerfasserIn  |4 aut 
700 1 |a Jick, Susan  |e VerfasserIn  |4 aut 
700 1 |a Sahm, Katharina  |d 1985-  |e VerfasserIn  |0 (DE-588)1048541762  |0 (DE-627)780594371  |0 (DE-576)402374452  |4 aut 
700 1 |a Platten, Michael  |d 1971-  |e VerfasserIn  |0 (DE-588)121627780  |0 (DE-627)081431848  |0 (DE-576)261969811  |4 aut 
700 1 |a Hau, Peter  |e VerfasserIn  |4 aut 
700 1 |a Seliger, Corinna  |e VerfasserIn  |0 (DE-588)1207951587  |0 (DE-627)1694290972  |4 aut 
773 0 8 |i Enthalten in  |t Cancer medicine  |d Hoboken, NJ : Wiley, 2012  |g 9(2020), 3, Seite 1263-1275  |h Online-Ressource  |w (DE-627)71860153X  |w (DE-600)2659751-2  |w (DE-576)366682164  |x 2045-7634  |7 nnas  |a Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma 
773 1 8 |g volume:9  |g year:2020  |g number:3  |g pages:1263-1275  |g extent:13  |a Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma 
856 4 0 |u https://doi.org/10.1002/cam4.2767  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.2767  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200408 
993 |a Article 
994 |a 2020 
998 |g 1207951587  |a Seliger, Corinna  |m 1207951587:Seliger, Corinna  |d 910000  |d 911100  |e 910000PS1207951587  |e 911100PS1207951587  |k 0/910000/  |k 1/910000/911100/  |p 10  |y j 
998 |g 121627780  |a Platten, Michael  |m 121627780:Platten, Michael  |d 60000  |d 62700  |e 60000PP121627780  |e 62700PP121627780  |k 0/60000/  |k 1/60000/62700/  |p 8 
998 |g 1048541762  |a Sahm, Katharina  |m 1048541762:Sahm, Katharina  |d 60000  |d 62700  |e 60000PS1048541762  |e 62700PS1048541762  |k 0/60000/  |k 1/60000/62700/  |p 7 
999 |a KXP-PPN1694291367  |e 3620682119 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1694291367"],"doi":["10.1002/cam4.2767"]},"physDesc":[{"extent":"13 S."}],"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"zdb":["2659751-2"],"issn":["2045-7634"],"eki":["71860153X"]},"part":{"issue":"3","pages":"1263-1275","text":"9(2020), 3, Seite 1263-1275","volume":"9","year":"2020","extent":"13"},"pubHistory":["1.2012 -"],"recId":"71860153X","origin":[{"dateIssuedKey":"2012","publisherPlace":"Hoboken, NJ","publisher":"Wiley","dateIssuedDisp":"2012-"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Cancer medicine","title":"Cancer medicine"}],"note":["Gesehen am 07.05.13"],"disp":"Autoimmune diseases and immunosuppressive therapy in relation to the risk of gliomaCancer medicine"}],"title":[{"title":"Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma","title_sort":"Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma"}],"person":[{"role":"aut","display":"Anssar, Tareq Marius","given":"Tareq Marius","family":"Anssar"},{"family":"Leitzmann","given":"Michael F.","display":"Leitzmann, Michael F.","role":"aut"},{"role":"aut","display":"Linker, Ralf A.","given":"Ralf A.","family":"Linker"},{"role":"aut","display":"Meier, Christoph","given":"Christoph","family":"Meier"},{"family":"Becker","given":"Claudia","display":"Becker, Claudia","role":"aut"},{"display":"Jick, Susan","role":"aut","family":"Jick","given":"Susan"},{"display":"Sahm, Katharina","role":"aut","family":"Sahm","given":"Katharina"},{"display":"Platten, Michael","role":"aut","family":"Platten","given":"Michael"},{"role":"aut","display":"Hau, Peter","given":"Peter","family":"Hau"},{"family":"Seliger","given":"Corinna","display":"Seliger, Corinna","role":"aut"}],"language":["eng"],"origin":[{"dateIssuedDisp":"2020","dateIssuedKey":"2020"}],"recId":"1694291367","name":{"displayForm":["Tareq M. Anssar, Michael F. Leitzmann, Ralf A. Linker, Christoph Meier, Claudia Becker, Susan Jick, Katharina Sahm, Michael Platten, Peter Hau, Corinna Seliger"]},"note":["First published: 10 December 2019","Gesehen am 08.04.2020"]} 
SRT |a ANSSARTAREAUTOIMMUNE2020 

Similar Items