Relevance of donor-specific antibody monitoring after kidney transplantation: findings from the Collaborative Transplant Study and the Heidelberg Transplant Center
Monitoring of donor-specific HLA antibodies (DSA) has become part of the clinical routine in kidney transplantation. This paper gives a brief overview on data from the Collaborative Transplant Study (CTS) and the Heidelberg Transplant Center on the clinical relevance of post-transplant DSA monitorin...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 August 2019
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| In: |
HLA
Year: 2019, Jahrgang: 94, Heft: S2, Pages: 11-15 |
| ISSN: | 2059-2310 |
| DOI: | 10.1111/tan.13665 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/tan.13665 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.13665 
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| Verfasserangaben: | Caner Süsal, Güclü Aykut, Christian Morath, Alexander Fichtner, Christian Unterrainer, Sabine Scherer, Thuong H. Tran, Arianeb Mehrabi, Martin Zeier, Burkhard Tönshoff |
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| 520 | |a Monitoring of donor-specific HLA antibodies (DSA) has become part of the clinical routine in kidney transplantation. This paper gives a brief overview on data from the Collaborative Transplant Study (CTS) and the Heidelberg Transplant Center on the clinical relevance of post-transplant DSA monitoring in patients undergoing renal transplantation. The obtained findings underline the importance of DSA monitoring in the post-operative course in immunologically high-risk patients and patients with deterioration of graft function. Especially in patients with a pre-activated immune system, a gap in the immunosuppressive therapy appear to lead to persistence, reappearance or de novo occurrence of strong, complement-activating DSA, resulting in severe antibody-mediated rejection (AMR) and, without timely intervention, in AMR-related graft loss. | ||
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