Targeting phosphodiesterase-5 by vardenafil improves vascular graft function
Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2018
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| In: |
European journal of vascular and endovascular surgery
Year: 2018, Jahrgang: 56, Heft: 2, Pages: 256-263 |
| ISSN: | 1532-2165 |
| DOI: | 10.1016/j.ejvs.2018.03.025 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejvs.2018.03.025 Verlag, lizenzpflichtig, Volltext: https://www.ejves.com/article/S1078-5884(18)30166-7/abstract |
| Verfasserangaben: | Gábor Veres, Meike Hagenhoff, Harald Schmidt, Tamás Radovits, Sivakkanan Loganathan, Yang Bai, Sevil Korkmaz-Icöz, Paige Brlecic, Alex Ali Sayour, Matthias Karck, Gábor Szabó |
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| 520 | |a Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis that the phosphodiesterase-5 inhibitor vardenafil would protect vascular grafts against IR injury by upregulating the nitric oxide-cGMP pathway in the vessel wall of the bypass graft was investigated. | ||
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