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Targeting phosphodiesterase-5 by vardenafil improves vascular graft function

Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis...

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Bibliographische Detailangaben
Hauptverfasser: Veres, Gábor (VerfasserIn) , Hagenhoff, Meike (VerfasserIn) , Schmidt, Harald (VerfasserIn) , Radovits, Tamás (VerfasserIn) , Loganathan, Sivakkanan (VerfasserIn) , Bai, Yang (VerfasserIn) , Korkmaz-İçöz, Sevil (VerfasserIn) , Brlecic, Paige (VerfasserIn) , Sayour, Alex Ali (VerfasserIn) , Karck, Matthias (VerfasserIn) , Szabó, Gábor (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: September 2018
In: European journal of vascular and endovascular surgery
Year: 2018, Jahrgang: 56, Heft: 2, Pages: 256-263
ISSN:1532-2165
DOI:10.1016/j.ejvs.2018.03.025
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejvs.2018.03.025
Verlag, lizenzpflichtig, Volltext: https://www.ejves.com/article/S1078-5884(18)30166-7/abstract
Volltext
Verfasserangaben:Gábor Veres, Meike Hagenhoff, Harald Schmidt, Tamás Radovits, Sivakkanan Loganathan, Yang Bai, Sevil Korkmaz-Icöz, Paige Brlecic, Alex Ali Sayour, Matthias Karck, Gábor Szabó
Beschreibung
Zusammenfassung:Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis that the phosphodiesterase-5 inhibitor vardenafil would protect vascular grafts against IR injury by upregulating the nitric oxide-cGMP pathway in the vessel wall of the bypass graft was investigated.
Beschreibung:Gesehen am 09.04.2020
Beschreibung:Online Resource
ISSN:1532-2165
DOI:10.1016/j.ejvs.2018.03.025

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