Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party
Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated. We studied the long-term outcome of patients r...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 January 2018
|
| In: |
Bone marrow transplantation
Year: 2018, Jahrgang: 53, Heft: 5, Pages: 617-624 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/s41409-017-0067-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41409-017-0067-3 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41409-017-0067-3 
|
| Verfasserangaben: | Stephen P. Robinson, Ariane Boumendil, Herve Finel, Karl S. Peggs, Patrice Chevallier, Jorge Sierra, Jürgen Finke, Xavier Poiré, Natacha Maillard, Noël Milpied, Ibrahim Yakoub-Agha, Mickey Koh, Nicolaus Kröger, Arnon Nagler, Yener Koc, Sascha Dietrich, Silvia Montoto, Peter Dreger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1694461467 | ||
| 003 | DE-627 | ||
| 005 | 20230427095010.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200414s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41409-017-0067-3 |2 doi | |
| 035 | |a (DE-627)1694461467 | ||
| 035 | |a (DE-599)KXP1694461467 | ||
| 035 | |a (OCoLC)1341314452 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Robinson, Stephen |e VerfasserIn |0 (DE-588)1192544889 |0 (DE-627)1671096401 |4 aut | |
| 245 | 1 | 0 | |a Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma |b a retrospective study from the EBMT Lymphoma Working Party |c Stephen P. Robinson, Ariane Boumendil, Herve Finel, Karl S. Peggs, Patrice Chevallier, Jorge Sierra, Jürgen Finke, Xavier Poiré, Natacha Maillard, Noël Milpied, Ibrahim Yakoub-Agha, Mickey Koh, Nicolaus Kröger, Arnon Nagler, Yener Koc, Sascha Dietrich, Silvia Montoto, Peter Dreger |
| 264 | 1 | |c 15 January 2018 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.04.2020 | ||
| 520 | |a Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated. We studied the long-term outcome of patients receiving a RIST for MCL as reported to the EBMT. A total of 324 patients, median age 57 years (range 31-70), underwent a RIST between 2000 and 2008; 43% of the patients had received >3 lines of prior therapy, including an autoSCT in 46%. Non-relapse mortality (NRM) was 10% at 100 days and 24% at 1 year and was lower for patients receiving anti-thymocyte globulin (ATG)/ALG (RR 0.59, p = 0.046). After a median follow-up of 72 months (range 3-159), 118 patients relapsed at a median of 8 months post RIST (range 1-117). The cumulative incidence of relapse was 25% and 40% at 1 and 5 years, respectively, and was associated with chemorefractory disease (HR 0.49, p = 0.01) and the use of CAMPATH (HR 2.59, p = 0.0002). The 4-year progression-free survival rate and overall survival rate was 31 and 40%, respectively. RIST results in long-term disease-free survival in about 30% of the patients, including those patients relapsing after a prior autoSCT. | ||
| 700 | 1 | |a Dietrich, Sascha |d 1979- |e VerfasserIn |0 (DE-588)136406300 |0 (DE-627)694354635 |0 (DE-576)301003408 |4 aut | |
| 700 | 1 | |a Dreger, Peter |e VerfasserIn |0 (DE-588)1028891881 |0 (DE-627)732699894 |0 (DE-576)376320966 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Bone marrow transplantation |d London : Springer Nature, 1997 |g 53(2018), 5, Seite 617-624 |h Online-Ressource |w (DE-627)320433366 |w (DE-600)2004030-1 |w (DE-576)091012996 |x 1476-5365 |7 nnas |a Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma a retrospective study from the EBMT Lymphoma Working Party |
| 773 | 1 | 8 | |g volume:53 |g year:2018 |g number:5 |g pages:617-624 |g extent:8 |a Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma a retrospective study from the EBMT Lymphoma Working Party |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41409-017-0067-3 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41409-017-0067-3 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200414 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1028891881 |a Dreger, Peter |m 1028891881:Dreger, Peter |d 910000 |d 910100 |e 910000PD1028891881 |e 910100PD1028891881 |k 0/910000/ |k 1/910000/910100/ |p 28 | ||
| 998 | |g 136406300 |a Dietrich, Sascha |m 136406300:Dietrich, Sascha |d 910000 |d 910100 |e 910000PD136406300 |e 910100PD136406300 |k 0/910000/ |k 1/910000/910100/ |p 16 | ||
| 999 | |a KXP-PPN1694461467 |e 3622973501 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Robinson, Stephen","role":"aut","given":"Stephen","family":"Robinson"},{"role":"aut","given":"Sascha","display":"Dietrich, Sascha","family":"Dietrich"},{"display":"Dreger, Peter","given":"Peter","role":"aut","family":"Dreger"}],"name":{"displayForm":["Stephen P. Robinson, Ariane Boumendil, Herve Finel, Karl S. Peggs, Patrice Chevallier, Jorge Sierra, Jürgen Finke, Xavier Poiré, Natacha Maillard, Noël Milpied, Ibrahim Yakoub-Agha, Mickey Koh, Nicolaus Kröger, Arnon Nagler, Yener Koc, Sascha Dietrich, Silvia Montoto, Peter Dreger"]},"note":["Gesehen am 14.04.2020"],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["320433366"],"issn":["1476-5365"],"zdb":["2004030-1"]},"disp":"Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma a retrospective study from the EBMT Lymphoma Working PartyBone marrow transplantation","note":["Gesehen am 17.01.25"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"320433366","origin":[{"dateIssuedKey":"1997","dateIssuedDisp":"1997-","publisher":"Springer Nature ; Macmillan ; Nature Publishing Group","publisherPlace":"London ; Basingstoke ; London"}],"title":[{"title":"Bone marrow transplantation","title_sort":"Bone marrow transplantation"}],"part":{"volume":"53","text":"53(2018), 5, Seite 617-624","year":"2018","issue":"5","extent":"8","pages":"617-624"},"language":["eng"],"pubHistory":["Nachgewiesen 19.1997 -"]}],"physDesc":[{"extent":"8 S."}],"id":{"eki":["1694461467"],"doi":["10.1038/s41409-017-0067-3"]},"recId":"1694461467","origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"15 January 2018"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"title":[{"title_sort":"Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma","subtitle":"a retrospective study from the EBMT Lymphoma Working Party","title":"Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma"}]} | ||
| SRT | |a ROBINSONSTLONGTERMOU1520 | ||