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Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation

Isocitrate dehydrogenase 1 (IDH1) mutations are associated with improved survival in gliomas. Depending on the IDH1 status, TERT promoter mutations affect prognosis. IDH1 mutations are associated with alpha-thalassemia/mental retardation syndrome X-linked (ATRX) mutations and alternative lengthening...

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Hauptverfasser: Ventura Ferreira, Mónica Sofia (VerfasserIn) , Sørensen, Mia Dahl (VerfasserIn) , Pusch, Stefan (VerfasserIn) , Beier, Dagmar (VerfasserIn) , Bouillon, Anne-Sophie (VerfasserIn) , Kristensen, Bjarne Winther (VerfasserIn) , Brümmendorf, Tim Henrik (VerfasserIn) , Beier, Christoph-Patrick (VerfasserIn) , Beier, Fabian (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 January 2020
In: Journal of neuro-oncology
Year: 2020, Jahrgang: 147, Heft: 1, Pages: 1-14
ISSN:1573-7373
DOI:10.1007/s11060-020-03394-y
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11060-020-03394-y
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Verfasserangaben:Monica Sofia Ventura Ferreira, Mia Dahl Sørensen, Stefan Pusch, Dagmar Beier, Anne-Sophie Bouillon, Bjarne Winther Kristensen, Tim Henrik Brümmendorf, Christoph Patrick Beier, Fabian Beier

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520 |a Isocitrate dehydrogenase 1 (IDH1) mutations are associated with improved survival in gliomas. Depending on the IDH1 status, TERT promoter mutations affect prognosis. IDH1 mutations are associated with alpha-thalassemia/mental retardation syndrome X-linked (ATRX) mutations and alternative lengthening of telomeres (ALT), suggesting an interaction between IDH1 and telomeres. However, little is known how IDH1 mutations affect telomere maintenance. 
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