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Analysis of data collected in the European Society for Blood and Marrow Transplantation (EBMT) registry on a cohort of lymphoma patients receiving plerixafor

Plerixafor + granulocyte-colony stimulating factor (G-CSF) is administered to patients with lymphoma who are poor mobilizers of hematopoietic stem cells (HSCs) in Europe. This international, multicenter, non-interventional registry study (NCT01362972) evaluated long-term follow-up of patients with l...

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Hauptverfasser: Sureda, Anna (VerfasserIn) , Dreger, Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2020
In: Bone marrow transplantation
Year: 2019, Jahrgang: 55, Heft: 3, Pages: 613-622
ISSN:1476-5365
DOI:10.1038/s41409-019-0693-z
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41409-019-0693-z
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41409-019-0693-z
Volltext
Verfasserangaben:Anna Sureda, Christian Chabannon, Tamás Masszi, David Pohlreich, Christof Scheid, Catherine Thieblemont, Björn E. Wahlin, Ioanna Sakellarim, Nigel Russell, Andrea Janikova, Anna Dabrowska-Iwanicka, Cyrille Touzeau, Albert Esquirol, Esa Jantunen, Steffie van der Werf, Paul Bosman, Ariane Boumendil, Qianying Liu, Marina Celanovic, Silvia Montoto, Peter Dreger
Beschreibung
Zusammenfassung:Plerixafor + granulocyte-colony stimulating factor (G-CSF) is administered to patients with lymphoma who are poor mobilizers of hematopoietic stem cells (HSCs) in Europe. This international, multicenter, non-interventional registry study (NCT01362972) evaluated long-term follow-up of patients with lymphoma who received plerixafor for HSC mobilization versus other mobilization methods. Propensity score matching was conducted to balance baseline characteristics between comparison groups. The following mobilization regimens were compared: G-CSF + plerixafor (G + P) versus G-CSF alone; G + P versus G-CSF + chemotherapy (G + C); and G-CSF + plerixafor + chemotherapy (G + P + C) versus G + C. The primary outcomes were progression-free survival (PFS), overall survival (OS), and cumulative incidence of relapse (CIR). Overall, 313/3749 (8.3%) eligible patients were mobilized with plerixafor-containing regimens. After propensity score matching, 70 versus 36 patients were matched in the G + P versus G-CSF alone cohort, 124 versus 124 in the G + P versus G + C cohort, and 130 versus 130 in the G + P + C versus G + C cohort. For both PFS and OS, the upper bound of confidence interval for the hazard ratio was >1.3 for all comparisons, implying that non-inferiority was not demonstrated. No major differences in PFS, OS, and CIR were observed between the plerixafor and comparison groups.
Beschreibung:Published online: 30 September 2019
Gesehen am 16.04.2020
Beschreibung:Online Resource
ISSN:1476-5365
DOI:10.1038/s41409-019-0693-z

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