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Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: results from the ETOP Lungscape Project

Reported prevalence of driver gene mutations in non-small-cell lung cancer (NSCLC) is highly variable and clinical correlations are emerging. Using NSCLC biomaterial and clinical data from the European Thoracic Oncology Platform Lungscape iBiobank, we explore the epidemiology of mutations and associ...

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Main Authors: Kerr, Keith M. (Author) , Dafni, U. (Author) , Schulze, K. (Author) , Thunnissen, E. (Author) , Bubendorf, L. (Author) , Hager, H. (Author) , Finn, S. (Author) , Biernat, W. (Author) , Vliegen, L. (Author) , Losa, J. H. (Author) , Marchetti, A. (Author) , Cheney, R. (Author) , Warth, Arne (Author) , Speel, E. -J. (Author) , Blackhall, F. (Author) , Monkhorst, K. (Author) , Jantus Lewintre, E. (Author) , Tischler, V. (Author) , Clark, C. (Author) , Bertran-Alamillo, J. (Author) , Meldgaard, P. (Author) , Gately, K. (Author) , Wrona, A. (Author) , Vandenberghe, P. (Author) , Felip, E. (Author) , De Luca, G. (Author) , Savic, S. (Author) , Muley, Thomas (Author) , Smit, E. F. (Author) , Dingemans, A. -M. C. (Author) , Priest, L. (Author) , Baas, P. (Author) , Camps, C. (Author) , Weder, W. (Author) , Polydoropoulou, V. (Author) , Geiger, T. R. (Author) , Kammler, R. (Author) , Sumiyoshi, T. (Author) , Molina, M. A. (Author) , Shames, D. S. (Author) , Stahel, R. A. (Author) , Peters, S. (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: Annals of oncology
Year: 2017, Volume: 29, Issue: 1, Pages: 200-208
ISSN:1569-8041
DOI:10.1093/annonc/mdx629
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/annonc/mdx629
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0923753419349877
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Author Notes:K. M. Kerr, U. Dafni, K. Schulze, E. Thunnissen, L. Bubendorf, H. Hager, S. Finn, W. Biernat, L. Vliegen, J.H. Losa, A. Marchetti, R. Cheney, A. Warth, E.-J. Speel, F. Blackhall, K. Monkhorst, E. Jantus Lewintre, V. Tischler, C. Clark, J. Bertran-Alamillo, P. Meldgaard, K. Gately, A. Wrona, P. Vandenberghe, E. Felip, G. De Luca, S. Savic, T. Muley, E.F. Smit, A.-M.C. Dingemans, L. Priest, P. Baas, C. Camps, W. Weder, V. Polydoropoulou, T.R. Geiger, R. Kammler, T. Sumiyoshi, M.A. Molina, D.S. Shames, R.A. Stahel & S. Peters, for the ETOP Lungscape Consortium
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Summary:Reported prevalence of driver gene mutations in non-small-cell lung cancer (NSCLC) is highly variable and clinical correlations are emerging. Using NSCLC biomaterial and clinical data from the European Thoracic Oncology Platform Lungscape iBiobank, we explore the epidemiology of mutations and association to clinicopathologic features and patient outcome (relapse-free survival, time-to-relapse, overall survival).
Item Description:Published online 23 November 2017
Gesehen am 16.04.2020
Physical Description:Online Resource
ISSN:1569-8041
DOI:10.1093/annonc/mdx629

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