Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis
Background - Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF. - Methods - Bronchoalveolar lavage...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 June 2018
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| In: |
Journal of cystic fibrosis
Year: 2018, Jahrgang: 17, Heft: 6, Pages: 715-722 |
| ISSN: | 1873-5010 |
| DOI: | 10.1016/j.jcf.2018.05.006 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jcf.2018.05.006 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1569199318305885 
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| Verfasserangaben: | Samuel T. Montgomery, A. Susanne Dittrich, Luke W. Garratt, Lidija Turkovic, Dario L. Frey, Stephen M. Stick, Marcus A. Mall, Anthony Kicic |
MARC
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| 245 | 1 | 0 | |a Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis |c Samuel T. Montgomery, A. Susanne Dittrich, Luke W. Garratt, Lidija Turkovic, Dario L. Frey, Stephen M. Stick, Marcus A. Mall, Anthony Kicic |
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| 520 | |a Background - Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF. - Methods - Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans. - Results - IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p<0.0001), neutrophils (p<0.0001) and NE activity (p<0.01 and p<0.001). IL-1α had the strongest association with structural lung disease (p <0.01) in the absence of infection (uninfected: p<0.01 vs. infected: p=0.122). - Conclusion - Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target. | ||
| 650 | 4 | |a Airway epithelium | |
| 650 | 4 | |a Cystic fibrosis | |
| 650 | 4 | |a Hypoxia | |
| 650 | 4 | |a Interleukin (IL)-1 | |
| 650 | 4 | |a Mucus | |
| 650 | 4 | |a Neutrophilic inflammation | |
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