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Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort

Studies to date have reported several associations between single nucleotide polymorphisms (SNPs) and cancer related fatigue (CRF), but have been limited by small sample sizes, missing adjustment for relevant covariates or multiple testing, as well as varying CRF definitions, i.e. time and method of...

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Hauptverfasser: Maurer, Tabea (VerfasserIn) , Behrens, S. (VerfasserIn) , Jung, A. Y. (VerfasserIn) , Obi, N. (VerfasserIn) , Thöne, K. (VerfasserIn) , Schmidt, Martina (VerfasserIn) , Becher, Heiko (VerfasserIn) , Chang-Claude, Jenny (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 18 May 2018
In: Brain, behavior and immunity
Year: 2018, Jahrgang: 73, Pages: 252-260
ISSN:1090-2139
DOI:10.1016/j.bbi.2018.05.009
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bbi.2018.05.009
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0889159118301806
Volltext
Verfasserangaben:T. Kühl, S. Behrens, A.Y. Jung, N. Obi, K. Thöne, M.E. Schmidt, H. Becher, J. Chang-Claude
Beschreibung
Zusammenfassung:Studies to date have reported several associations between single nucleotide polymorphisms (SNPs) and cancer related fatigue (CRF), but have been limited by small sample sizes, missing adjustment for relevant covariates or multiple testing, as well as varying CRF definitions, i.e. time and method of assessment. This study aimed to validate previously reported associations using the largest independent breast cancer sample to date and to evaluate further functional cytokine variants in relation to total CRF and all relevant CRF subdomains (physical, cognitive, and affective CRF).
Beschreibung:Gesehen am 16.04.2020
Beschreibung:Online Resource
ISSN:1090-2139
DOI:10.1016/j.bbi.2018.05.009

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