The role of visceral and subcutaneous adipose tissue measurements and their ratio by magnetic resonance imaging in subjects with prediabetes, diabetes and healthy controls from a general population without cardiovascular disease
Objective: To study the relationship of area- and volumetric-based visceral and subcutaneous adipose tissue (VAT and SAT) by MRI and their ratio in subjects with impaired glucose metabolism from the general population. Methods: Subjects from a population-based cohort with established prediabetes, di...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
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| In: |
British journal of radiology
Year: 2018, Jahrgang: 91, Heft: 1089 |
| ISSN: | 1748-880X |
| DOI: | 10.1259/bjr.20170808 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1259/bjr.20170808 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223151/ 
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| Verfasserangaben: | Corinna Storz, Sophia D Heber, Susanne Rospleszcz, Jürgen Machann, Sabine Sellner, Konstantin Nikolaou, Roberto Lorbeer, Sergios Gatidis, Stefanie Elser, Annette Peters, Christopher L Schlett, Fabian Bamberg |
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| 245 | 1 | 4 | |a The role of visceral and subcutaneous adipose tissue measurements and their ratio by magnetic resonance imaging in subjects with prediabetes, diabetes and healthy controls from a general population without cardiovascular disease |c Corinna Storz, Sophia D Heber, Susanne Rospleszcz, Jürgen Machann, Sabine Sellner, Konstantin Nikolaou, Roberto Lorbeer, Sergios Gatidis, Stefanie Elser, Annette Peters, Christopher L Schlett, Fabian Bamberg |
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| 520 | |a Objective: To study the relationship of area- and volumetric-based visceral and subcutaneous adipose tissue (VAT and SAT) by MRI and their ratio in subjects with impaired glucose metabolism from the general population. Methods: Subjects from a population-based cohort with established prediabetes, diabetes and healthy controls without prior cardiovascular diseases underwent 3 T MRI. VAT and SAT were assessed as total volume and area on a single slice, and their ratio (VAT/SAT) was calculated. Clinical covariates and cardiovascular risk factors, such as hypertension and glycemic state were assessed in standardized fashion. Univariate and adjusted analyses were conducted. Results: Among 384 subjects (age: 56.2 ± 9.2 years, 58.1% male) with complete MRI data available, volumetric and single-slice VAT, SAT and VAT/SAT ratio were strongly correlated (all >r = 0.89). Similarly, VAT/SATvolume ratio was strongly correlated with VATvolume but not with SAT (r = 0.72 and r = −0.21, respectively). Significant higher levels of VAT, SAT and VAT/SAT ratio were found in subjects with impaired glucose metabolism (all p ≤ 0.01). After adjustment for potential cardiovascular confounders, VATvolume and VAT/SATvolume ratio remained significantly higher in subjects with impaired glucose metabolism (VATvolume = 6.9 ± 2.5 l and 3.4 ± 2.3 l; VAT/SATvolume ratio = 0.82 ± 0.34 l and 0.49 ± 0.29 l in patients with diabetes and controls, respectively, all p < 0.02), whereas the association for SATvolume attenuated. Additionally, there was a decreasing effect of glycemic status on VAT/SATvolume ratio with increasing body mass index and waist circumference (p < 0.05). Conclusions: VATvolume and VAT/SATvolume ratio are associated with impaired glucose metabolism, independent of cardiovascular risk factors or MRI-based quantification technique, with a decreasing effect of VAT/SATvolume ratio in obese subjects. Advances in knowledge: Quantification of VATvolume and VAT/SATvolume ratio by MRI represents a reproducable biomarker associated with cardiometabolic risk factors in subjects with impaired glucose metabolism, while the association of VAT/SATvolume ratio with glycemic state is attenuated in obese subjects. | ||
| 700 | 1 | |a Heber, Sophia D |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rospleszcz, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Machann, Jürgen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sellner, Sabine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nikolaou, Konstantin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lorbeer, Roberto |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gatidis, Sergios |e VerfasserIn |4 aut | |
| 700 | 1 | |a Elser, Stefanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peters, Annette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlett, Christopher L. |d 1983- |e VerfasserIn |0 (DE-588)1022729977 |0 (DE-627)717033945 |0 (DE-576)36586398X |4 aut | |
| 700 | 1 | |a Bamberg, Fabian |e VerfasserIn |4 aut | |
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