Modeling the effect of hypoxia and DNA repair inhibition on cell survival photon irradiation
Mechanistic approaches to modeling the effects of ionizing radiation on cells are on the rise, promising a better understanding of predictions and higher flexibility concerning conditions to be accounted for. In this work we modified and extended a previously published mechanistic model of cell surv...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 November 2019
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| In: |
International journal of molecular sciences
Year: 2019, Jahrgang: 20, Heft: 23 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms20236054 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms20236054 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/20/23/6054 
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| Verfasserangaben: | Hans Liew, Carmen Klein, Frank T. Zenke, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Andrea Mairani |
| Zusammenfassung: | Mechanistic approaches to modeling the effects of ionizing radiation on cells are on the rise, promising a better understanding of predictions and higher flexibility concerning conditions to be accounted for. In this work we modified and extended a previously published mechanistic model of cell survival after photon irradiation under hypoxia to account for radiosensitization caused by deficiency or inhibition of DNA damage repair enzymes. The model is shown to be capable of describing the survival data of cells with DNA damage repair deficiency, both under norm- and hypoxia. We find that our parameterization of radiosensitization is invariant under change of oxygen status, indicating that the relevant parameters for both mechanisms can be obtained independently and introduced freely to the model to predict their combined effect. |
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| Beschreibung: | Gesehen am 20.04.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms20236054 |