Modeling the effect of hypoxia and DNA repair inhibition on cell survival photon irradiation
Mechanistic approaches to modeling the effects of ionizing radiation on cells are on the rise, promising a better understanding of predictions and higher flexibility concerning conditions to be accounted for. In this work we modified and extended a previously published mechanistic model of cell surv...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 November 2019
|
| In: |
International journal of molecular sciences
Year: 2019, Jahrgang: 20, Heft: 23 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms20236054 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms20236054 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/20/23/6054 
|
| Verfasserangaben: | Hans Liew, Carmen Klein, Frank T. Zenke, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Andrea Mairani |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1694957330 | ||
| 003 | DE-627 | ||
| 005 | 20220818044134.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200420s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms20236054 |2 doi | |
| 035 | |a (DE-627)1694957330 | ||
| 035 | |a (DE-599)KXP1694957330 | ||
| 035 | |a (OCoLC)1341315649 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Liew, Hans |d 1994- |e VerfasserIn |0 (DE-588)1197708936 |0 (DE-627)1679441264 |4 aut | |
| 245 | 1 | 0 | |a Modeling the effect of hypoxia and DNA repair inhibition on cell survival photon irradiation |c Hans Liew, Carmen Klein, Frank T. Zenke, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Andrea Mairani |
| 264 | 1 | |c 30 November 2019 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.04.2020 | ||
| 520 | |a Mechanistic approaches to modeling the effects of ionizing radiation on cells are on the rise, promising a better understanding of predictions and higher flexibility concerning conditions to be accounted for. In this work we modified and extended a previously published mechanistic model of cell survival after photon irradiation under hypoxia to account for radiosensitization caused by deficiency or inhibition of DNA damage repair enzymes. The model is shown to be capable of describing the survival data of cells with DNA damage repair deficiency, both under norm- and hypoxia. We find that our parameterization of radiosensitization is invariant under change of oxygen status, indicating that the relevant parameters for both mechanisms can be obtained independently and introduced freely to the model to predict their combined effect. | ||
| 650 | 4 | |a DNA repair | |
| 650 | 4 | |a hypoxia | |
| 650 | 4 | |a ionizing radiation | |
| 650 | 4 | |a modeling | |
| 650 | 4 | |a radiosensitizer | |
| 700 | 1 | |a Klein, Carmen |d 1989- |e VerfasserIn |0 (DE-588)1203165900 |0 (DE-627)1687982678 |4 aut | |
| 700 | 1 | |a Zenke, Frank T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Abdollahi, Amir |e VerfasserIn |0 (DE-588)129612715 |0 (DE-627)474757765 |0 (DE-576)297748874 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Dokić, Ivana |e VerfasserIn |0 (DE-588)1024109208 |0 (DE-627)719434378 |0 (DE-576)367945789 |4 aut | |
| 700 | 1 | |a Mairani, Andrea |e VerfasserIn |0 (DE-588)1116742179 |0 (DE-627)870669281 |0 (DE-576)478592493 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d Basel : Molecular Diversity Preservation International, 2000 |g 20(2019,23) Art.-Nr. 6054, 11 Seiten |h Online-Ressource |w (DE-627)316340715 |w (DE-600)2019364-6 |w (DE-576)281194653 |x 1422-0067 |7 nnas |a Modeling the effect of hypoxia and DNA repair inhibition on cell survival photon irradiation |
| 773 | 1 | 8 | |g volume:20 |g year:2019 |g number:23 |g extent:11 |a Modeling the effect of hypoxia and DNA repair inhibition on cell survival photon irradiation |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms20236054 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1422-0067/20/23/6054 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200420 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1116742179 |a Mairani, Andrea |m 1116742179:Mairani, Andrea |d 50000 |e 50000PM1116742179 |k 0/50000/ |p 7 |y j | ||
| 998 | |g 1024109208 |a Dokić, Ivana |m 1024109208:Dokić, Ivana |d 910000 |d 911400 |e 910000PD1024109208 |e 911400PD1024109208 |k 0/910000/ |k 1/910000/911400/ |p 6 | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 5 | ||
| 998 | |g 129612715 |a Abdollahi, Amir |m 129612715:Abdollahi, Amir |d 910000 |d 911400 |e 910000PA129612715 |e 911400PA129612715 |k 0/910000/ |k 1/910000/911400/ |p 4 | ||
| 998 | |g 1203165900 |a Klein, Carmen |m 1203165900:Klein, Carmen |d 140000 |e 140000PK1203165900 |k 0/140000/ |p 2 | ||
| 998 | |g 1197708936 |a Liew, Hans |m 1197708936:Liew, Hans |d 130000 |e 130000PL1197708936 |k 0/130000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1694957330 |e 3626981746 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.3390/ijms20236054"],"eki":["1694957330"]},"name":{"displayForm":["Hans Liew, Carmen Klein, Frank T. Zenke, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Andrea Mairani"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"note":["Gesehen am 20.04.2020"],"title":[{"title":"Modeling the effect of hypoxia and DNA repair inhibition on cell survival photon irradiation","title_sort":"Modeling the effect of hypoxia and DNA repair inhibition on cell survival photon irradiation"}],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"30 November 2019"}],"relHost":[{"titleAlt":[{"title":"IJMS"}],"pubHistory":["1.2000 -"],"part":{"year":"2019","extent":"11","text":"20(2019,23) Art.-Nr. 6054, 11 Seiten","volume":"20","issue":"23"},"id":{"issn":["1422-0067","1661-6596"],"eki":["316340715"],"zdb":["2019364-6"]},"origin":[{"dateIssuedKey":"2000","publisherPlace":"Basel","dateIssuedDisp":"2000-","publisher":"Molecular Diversity Preservation International"}],"title":[{"title":"International journal of molecular sciences","title_sort":"International journal of molecular sciences"}],"note":["Gesehen am 17.09.20"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"recId":"316340715","physDesc":[{"extent":"Online-Ressource"}],"disp":"Modeling the effect of hypoxia and DNA repair inhibition on cell survival photon irradiationInternational journal of molecular sciences"}],"person":[{"family":"Liew","role":"aut","given":"Hans","display":"Liew, Hans"},{"display":"Klein, Carmen","role":"aut","given":"Carmen","family":"Klein"},{"family":"Zenke","given":"Frank T.","role":"aut","display":"Zenke, Frank T."},{"display":"Abdollahi, Amir","given":"Amir","role":"aut","family":"Abdollahi"},{"given":"Jürgen","role":"aut","family":"Debus","display":"Debus, Jürgen"},{"display":"Dokić, Ivana","family":"Dokić","given":"Ivana","role":"aut"},{"given":"Andrea","role":"aut","family":"Mairani","display":"Mairani, Andrea"}],"physDesc":[{"extent":"11 S."}],"recId":"1694957330"} | ||
| SRT | |a LIEWHANSKLMODELINGTH3020 | ||