Cover Image

COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescents

The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is rela...

Full description

Saved in:
Bibliographic Details
Main Authors: Millenet, Sabina (Author) , Nees, Frauke (Author) , Heintz, Stefan (Author) , Bach, Christiane (Author) , Frank, Josef (Author) , Vollstädt-Klein, Sabine (Author) , Bokde, Arun (Author) , Bromberg, Uli (Author) , Büchel, Christian (Author) , Quinlan, Erin B. (Author) , Desrivières, Sylvane (Author) , Fröhner, Juliane (Author) , Flor, Herta (Author) , Frouin, Vincent (Author) , Garavan, Hugh (Author) , Gowland, Penny (Author) , Heinz, Andreas (Author) , Ittermann, Bernd (Author) , Lemaire, Herve (Author) , Martinot, Jean-Luc (Author) , Martinot, Marie-Laure P. (Author) , Papadoulos, Dimitri O. (Author) , Paus, Tomáš (Author) , Poustka, Luise (Author) , Rietschel, Marcella (Author) , Smolka, Michael (Author) , Walter, Henrik (Author) , Whelan, Rob (Author) , Schumann, Gunter (Author) , Banaschewski, Tobias (Author) , Hohmann, Sarah (Author)
Format: Article (Journal)
Language:English
Published: 31 July 2018
In: Frontiers in genetics
Year: 2018, Volume: 9
ISSN:1664-8021
DOI:10.3389/fgene.2018.00284
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fgene.2018.00284
Get full text
Author Notes:Sabina K. Millenet, Frauke Nees, Stefan Heintz, Christiane Bach, Josef Frank, Sabine Vollstädt-Klein, Arun Bokde, Uli Bromberg, Christian Büchel, Erin B. Quinlan, Sylvane Desrivières, Juliane Fröhner, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Herve Lemaire, Jean-Luc Martinot, Marie-Laure P. Martinot, Dimitri O. Papadoulos, Tomáš Paus, Luise Poustka, Marcella Rietschel, Michael N. Smolka, Henrik Walter, Rob Whelan, Gunter Schumann, Tobias Banaschewski and Sarah Hohmann on behalf of the IMAGEN Consortium

MARC

LEADER 00000caa a2200000 c 4500
001 1694961222
003 DE-627
005 20241009143513.0
007 cr uuu---uuuuu
008 200420s2018 xx |||||o 00| ||eng c
024 7 |a 10.3389/fgene.2018.00284  |2 doi 
035 |a (DE-627)1694961222 
035 |a (DE-599)KXP1694961222 
035 |a (OCoLC)1341315494 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Millenet, Sabina  |d 1979-  |e VerfasserIn  |0 (DE-588)115850456X  |0 (DE-627)1020516062  |0 (DE-576)393976629  |4 aut 
245 1 0 |a COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescents  |c Sabina K. Millenet, Frauke Nees, Stefan Heintz, Christiane Bach, Josef Frank, Sabine Vollstädt-Klein, Arun Bokde, Uli Bromberg, Christian Büchel, Erin B. Quinlan, Sylvane Desrivières, Juliane Fröhner, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Herve Lemaire, Jean-Luc Martinot, Marie-Laure P. Martinot, Dimitri O. Papadoulos, Tomáš Paus, Luise Poustka, Marcella Rietschel, Michael N. Smolka, Henrik Walter, Rob Whelan, Gunter Schumann, Tobias Banaschewski and Sarah Hohmann on behalf of the IMAGEN Consortium 
264 1 |c 31 July 2018 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 20.04.2020 
520 |a The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is related both to the dopaminergic system and ADHD. In a large epidemiological sample of adolescents (N = 462; 16-17 years), we assessed the level of ADHD symptoms using the Strengths and Difficulties Questionnaire, social behavior using the Social Responsiveness Scale, and the allelic distribution of the dopaminergic catechol-O-methyltransferase (COMT) Val158Met polymorphism. We found a significant association between COMT and social impairment, insofar as Met-allele carriers showed increased levels of social impairment. Moreover, social impairment significantly determined an association between COMT and ADHD (explained variance: 19.09%). This effect did not significantly differ between males and females. COMT and social impairment might interactively affect ADHD symptomatology, and could thus represent significant gene-phenotypic risk factors for ADHD symptomatology. This might have interesting implications for prevention and intervention strategies with a focus on social behavior in genetically at-risk individuals. 
650 4 |a ADHD 
650 4 |a adolescence 
650 4 |a COMT 
650 4 |a moderation 
650 4 |a social impairment 
700 1 |a Nees, Frauke  |e VerfasserIn  |0 (DE-588)140286527  |0 (DE-627)703627244  |0 (DE-576)325389764  |4 aut 
700 1 |a Heintz, Stefan  |e VerfasserIn  |4 aut 
700 1 |a Bach, Christiane  |e VerfasserIn  |4 aut 
700 1 |a Frank, Josef  |e VerfasserIn  |4 aut 
700 1 |a Vollstädt-Klein, Sabine  |d 1973-  |e VerfasserIn  |0 (DE-588)128572744  |0 (DE-627)376206330  |0 (DE-576)188335935  |4 aut 
700 1 |a Bokde, Arun  |e VerfasserIn  |4 aut 
700 1 |a Bromberg, Uli  |e VerfasserIn  |4 aut 
700 1 |a Büchel, Christian  |e VerfasserIn  |4 aut 
700 1 |a Quinlan, Erin B.  |e VerfasserIn  |4 aut 
700 1 |a Desrivières, Sylvane  |e VerfasserIn  |4 aut 
700 1 |a Fröhner, Juliane  |e VerfasserIn  |4 aut 
700 1 |a Flor, Herta  |d 1954-  |e VerfasserIn  |0 (DE-588)110841816  |0 (DE-627)636273695  |0 (DE-576)160967732  |4 aut 
700 1 |a Frouin, Vincent  |e VerfasserIn  |4 aut 
700 1 |a Garavan, Hugh  |e VerfasserIn  |4 aut 
700 1 |a Gowland, Penny  |e VerfasserIn  |4 aut 
700 1 |a Heinz, Andreas  |e VerfasserIn  |4 aut 
700 1 |a Ittermann, Bernd  |e VerfasserIn  |4 aut 
700 1 |a Lemaire, Herve  |e VerfasserIn  |4 aut 
700 1 |a Martinot, Jean-Luc  |e VerfasserIn  |4 aut 
700 1 |a Martinot, Marie-Laure P.  |e VerfasserIn  |4 aut 
700 1 |a Papadoulos, Dimitri O.  |e VerfasserIn  |4 aut 
700 1 |a Paus, Tomáš  |e VerfasserIn  |4 aut 
700 1 |a Poustka, Luise  |e VerfasserIn  |0 (DE-588)1032378239  |0 (DE-627)738388688  |0 (DE-576)380005190  |4 aut 
700 1 |a Rietschel, Marcella  |d 1957-  |e VerfasserIn  |0 (DE-588)112785751  |0 (DE-627)505574020  |0 (DE-576)289742307  |4 aut 
700 1 |a Smolka, Michael  |e VerfasserIn  |0 (DE-588)1073229319  |0 (DE-627)828684685  |0 (DE-576)43475286X  |4 aut 
700 1 |a Walter, Henrik  |e VerfasserIn  |4 aut 
700 1 |a Whelan, Rob  |e VerfasserIn  |4 aut 
700 1 |a Schumann, Gunter  |e VerfasserIn  |4 aut 
700 1 |a Banaschewski, Tobias  |d 1961-  |e VerfasserIn  |0 (DE-588)115856110  |0 (DE-627)507227301  |0 (DE-576)178364703  |4 aut 
700 1 |a Hohmann, Sarah  |d 1978-  |e VerfasserIn  |0 (DE-588)131743473  |0 (DE-627)513596542  |0 (DE-576)298711486  |4 aut 
773 0 8 |i Enthalten in  |t Frontiers in genetics  |d Lausanne : Frontiers Media, 2010  |g 9(2018) Artikel-Nummer 284, 8 Seiten  |h Online-Ressource  |w (DE-627)65799829X  |w (DE-600)2606823-0  |w (DE-576)343624826  |x 1664-8021  |7 nnas  |a COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescents 
773 1 8 |g volume:9  |g year:2018  |g extent:8  |a COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescents 
856 4 0 |u https://doi.org/10.3389/fgene.2018.00284  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext  |7 1 
951 |a AR 
992 |a 20200420 
993 |a Article 
994 |a 2018 
998 |g 115856110  |a Banaschewski, Tobias  |m 115856110:Banaschewski, Tobias  |d 60000  |e 60000PB115856110  |k 0/60000/  |p 30 
998 |g 112785751  |a Rietschel, Marcella  |m 112785751:Rietschel, Marcella  |d 60000  |e 60000PR112785751  |k 0/60000/  |p 25 
998 |g 1032378239  |a Poustka, Luise  |m 1032378239:Poustka, Luise  |p 24 
998 |g 110841816  |a Flor, Herta  |m 110841816:Flor, Herta  |d 60000  |e 60000PF110841816  |k 0/60000/  |p 13 
998 |g 128572744  |a Vollstädt-Klein, Sabine  |m 128572744:Vollstädt-Klein, Sabine  |d 60000  |e 60000PV128572744  |k 0/60000/  |p 6 
998 |g 140286527  |a Nees, Frauke  |m 140286527:Nees, Frauke  |d 60000  |e 60000PN140286527  |k 0/60000/  |p 2 
998 |g 115850456X  |a Millenet, Sabina  |m 115850456X:Millenet, Sabina  |d 60000  |e 60000PM115850456X  |k 0/60000/  |p 1  |x j 
999 |a KXP-PPN1694961222  |e 362699158X 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title_sort":"COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescents","title":"COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescents"}],"note":["Gesehen am 20.04.2020"],"origin":[{"dateIssuedDisp":"31 July 2018","dateIssuedKey":"2018"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"8 S."}],"name":{"displayForm":["Sabina K. Millenet, Frauke Nees, Stefan Heintz, Christiane Bach, Josef Frank, Sabine Vollstädt-Klein, Arun Bokde, Uli Bromberg, Christian Büchel, Erin B. Quinlan, Sylvane Desrivières, Juliane Fröhner, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Herve Lemaire, Jean-Luc Martinot, Marie-Laure P. Martinot, Dimitri O. Papadoulos, Tomáš Paus, Luise Poustka, Marcella Rietschel, Michael N. Smolka, Henrik Walter, Rob Whelan, Gunter Schumann, Tobias Banaschewski and Sarah Hohmann on behalf of the IMAGEN Consortium"]},"recId":"1694961222","relHost":[{"id":{"zdb":["2606823-0"],"issn":["1664-8021"],"eki":["65799829X"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"65799829X","disp":"COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescentsFrontiers in genetics","type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Frontiers in genetics","title_sort":"Frontiers in genetics"}],"pubHistory":["1.2010 -"],"note":["Gesehen am 03.05.11"],"origin":[{"publisherPlace":"Lausanne","publisher":"Frontiers Media","dateIssuedKey":"2010","dateIssuedDisp":"2010-"}],"part":{"text":"9(2018) Artikel-Nummer 284, 8 Seiten","extent":"8","volume":"9","year":"2018"},"language":["eng"]}],"id":{"doi":["10.3389/fgene.2018.00284"],"eki":["1694961222"]},"person":[{"role":"aut","given":"Sabina","family":"Millenet","display":"Millenet, Sabina"},{"family":"Nees","display":"Nees, Frauke","given":"Frauke","role":"aut"},{"role":"aut","given":"Stefan","display":"Heintz, Stefan","family":"Heintz"},{"display":"Bach, Christiane","family":"Bach","role":"aut","given":"Christiane"},{"family":"Frank","display":"Frank, Josef","role":"aut","given":"Josef"},{"given":"Sabine","role":"aut","display":"Vollstädt-Klein, Sabine","family":"Vollstädt-Klein"},{"role":"aut","given":"Arun","family":"Bokde","display":"Bokde, Arun"},{"role":"aut","given":"Uli","family":"Bromberg","display":"Bromberg, Uli"},{"role":"aut","given":"Christian","family":"Büchel","display":"Büchel, Christian"},{"given":"Erin B.","role":"aut","display":"Quinlan, Erin B.","family":"Quinlan"},{"given":"Sylvane","role":"aut","display":"Desrivières, Sylvane","family":"Desrivières"},{"role":"aut","given":"Juliane","display":"Fröhner, Juliane","family":"Fröhner"},{"given":"Herta","role":"aut","display":"Flor, Herta","family":"Flor"},{"family":"Frouin","display":"Frouin, Vincent","role":"aut","given":"Vincent"},{"family":"Garavan","display":"Garavan, Hugh","role":"aut","given":"Hugh"},{"role":"aut","given":"Penny","family":"Gowland","display":"Gowland, Penny"},{"family":"Heinz","display":"Heinz, Andreas","role":"aut","given":"Andreas"},{"display":"Ittermann, Bernd","family":"Ittermann","given":"Bernd","role":"aut"},{"given":"Herve","role":"aut","display":"Lemaire, Herve","family":"Lemaire"},{"family":"Martinot","display":"Martinot, Jean-Luc","given":"Jean-Luc","role":"aut"},{"family":"Martinot","display":"Martinot, Marie-Laure P.","given":"Marie-Laure P.","role":"aut"},{"role":"aut","given":"Dimitri O.","display":"Papadoulos, Dimitri O.","family":"Papadoulos"},{"given":"Tomáš","role":"aut","family":"Paus","display":"Paus, Tomáš"},{"role":"aut","given":"Luise","family":"Poustka","display":"Poustka, Luise"},{"display":"Rietschel, Marcella","family":"Rietschel","role":"aut","given":"Marcella"},{"given":"Michael","role":"aut","display":"Smolka, Michael","family":"Smolka"},{"family":"Walter","display":"Walter, Henrik","given":"Henrik","role":"aut"},{"display":"Whelan, Rob","family":"Whelan","given":"Rob","role":"aut"},{"role":"aut","given":"Gunter","display":"Schumann, Gunter","family":"Schumann"},{"role":"aut","given":"Tobias","family":"Banaschewski","display":"Banaschewski, Tobias"},{"role":"aut","given":"Sarah","display":"Hohmann, Sarah","family":"Hohmann"}],"language":["eng"]} 
SRT |a MILLENETSACOMTVAL1583120 

Similar Items