M2 macrophage marker chitinase 3-like 2 (CHI3L2) associates with progression of conventional renal cell carcinoma
Background/Aim: In spite of early detection, appoximately 15% of the small renal cell carcinomas (RCC) will develop metastasis within 5 years follow-up. The aim of this study was to identify new biomarkers to estimate the postoperative relapse of the most common conventional RCC. Patients and Method...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[December 2019]
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| In: |
Anticancer research
Year: 2019, Jahrgang: 39, Heft: 12, Pages: 6939-6943 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.13915 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.13915 Verlag, lizenzpflichtig, Volltext: http://ar.iiarjournals.org/content/39/12/6939 
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| Verfasserangaben: | Csaba Pusztai, Maria V. Yusenko, Daniel Banyai, Arpad Szanto, and Gyula Kovacs |
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| 245 | 1 | 0 | |a M2 macrophage marker chitinase 3-like 2 (CHI3L2) associates with progression of conventional renal cell carcinoma |c Csaba Pusztai, Maria V. Yusenko, Daniel Banyai, Arpad Szanto, and Gyula Kovacs |
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| 520 | |a Background/Aim: In spite of early detection, appoximately 15% of the small renal cell carcinomas (RCC) will develop metastasis within 5 years follow-up. The aim of this study was to identify new biomarkers to estimate the postoperative relapse of the most common conventional RCC. Patients and Methods: Tissue multi arrays of conventional RCC without metastasis at the time of operation from a cohort of 634 patients were analysed by immunohistochemistry for expression of the chitinase 3-like protein 2 (CHI3L2). Cancer specific survival of patients was estimated with Kaplan-Meier analysis, univariate and multivariate Cox regression models. Results: Kaplan-Meier analysis estimated a shorter cancer-free survival for patients with CHI3L2 positive tumors. In multivariate analysis, the CHI3L2 positivity associated with a 3.5 times higher risk for tumor relapse (p<0.001). Conclusion: Expression of CHI3L2 in tumor cells of conventional RCC define a group of patients at high risk for postoperative progression. | ||
| 650 | 4 | |a CHI3L2 | |
| 650 | 4 | |a Conventional renal cell carcinoma | |
| 650 | 4 | |a immunohistochemistry | |
| 650 | 4 | |a postoperative tumor relapse | |
| 650 | 4 | |a tissue microarray | |
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