Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium
Solid tumors are covered by stroma, which is hypoxic in nature and composed of various non-malignant components such as endothelial cells, fibroblasts, and pericytes that support tumor growth. Tumor stroma represents a mechanical barrier for tumor infiltration of CD8+ effector T cells in particular....
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 July 2018
|
| In: |
Molecular carcinogenesis
Year: 2018, Volume: 57, Issue: 11, Pages: 1664-1671 |
| ISSN: | 1098-2744 |
| DOI: | 10.1002/mc.22879 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/mc.22879 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.22879 
|
| Author Notes: | Vinod Nadella, Sandhya Singh, Aklank Jain, Manju Jain, Karen M. Vasquez, Ashok Sharma, Pranay Tanwar, Goura Kishore Rath, Hridayesh Prakash |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1694969649 | ||
| 003 | DE-627 | ||
| 005 | 20220818044452.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200420s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/mc.22879 |2 doi | |
| 035 | |a (DE-627)1694969649 | ||
| 035 | |a (DE-599)KXP1694969649 | ||
| 035 | |a (OCoLC)1341315769 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Nadella, Vinod |e VerfasserIn |0 (DE-588)1208735365 |0 (DE-627)1695549848 |4 aut | |
| 245 | 1 | 0 | |a Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium |c Vinod Nadella, Sandhya Singh, Aklank Jain, Manju Jain, Karen M. Vasquez, Ashok Sharma, Pranay Tanwar, Goura Kishore Rath, Hridayesh Prakash |
| 246 | 3 | 3 | |a Low dose radiation primed iNOS+M1macrophages modulate angiogenic programming of tumor derived endothelium |
| 264 | 1 | |c 23 July 2018 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.04.2020 | ||
| 520 | |a Solid tumors are covered by stroma, which is hypoxic in nature and composed of various non-malignant components such as endothelial cells, fibroblasts, and pericytes that support tumor growth. Tumor stroma represents a mechanical barrier for tumor infiltration of CD8+ effector T cells in particular. In this context, our previous studies have demonstrated the therapeutic impact of Low-Dose Radiation (LDR)-primed and M1-retuned (iNOS+) peritumoral macrophages that produce inducible nitric oxide, have immunological roles on tumor infiltration of effector T cells, cancer-related inflammation, and subsequent tumor immune rejection in a mouse model of pancreatic cancer. These findings suggested a possible modification of tumor endothelium by LDR-primed macrophages. In line with these observations, here we demonstrate the influence of LDR in down-modulating HIF-1 in irradiated tumors in the course of polarization of irradiated tumor-associated macrophages toward an M1 phenotype. Furthermore, we demonstrate that M1 macrophages which are primed by LDR can directly influence angiogenic responses in eNOS+ endothelial cells which produce nitric oxide having both vascular and physiological roles. Furthermore, we demonstrate that naïve macrophages, upon differentiating to an M1 phenotype either by Th1 stimuli or LDR, potentially modify sphingosine-1-phosphate/VEGF-induced angiogenic signaling in tumor-derived endothelial cells with tumorigenic potential, thus indicating the significance of iNOS+ macrophages in modulating signaling in eNOS+ tumor-derived endothelium. Our study suggests that iNOS+ macrophages can activate tumor endothelium which may contribute to cancer-directed immunotherapy in particular. | ||
| 650 | 4 | |a angiogenesis | |
| 650 | 4 | |a endothelium | |
| 650 | 4 | |a gamma irradiation | |
| 650 | 4 | |a immune cells infiltration | |
| 650 | 4 | |a M1 macrophages | |
| 650 | 4 | |a tumor therapy | |
| 700 | 1 | |a Prakash, Hridayesh |e VerfasserIn |0 (DE-588)1154890228 |0 (DE-627)1016230605 |0 (DE-576)501296360 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular carcinogenesis |d New York, NY : Wiley Interscience, 1988 |g 57(2018), 11, Seite 1664-1671 |h Online-Ressource |w (DE-627)320416364 |w (DE-600)2001984-1 |w (DE-576)11461752X |x 1098-2744 |7 nnas |a Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium |
| 773 | 1 | 8 | |g volume:57 |g year:2018 |g number:11 |g pages:1664-1671 |g extent:8 |a Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium |
| 856 | 4 | 0 | |u https://doi.org/10.1002/mc.22879 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.22879 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200420 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1154890228 |a Prakash, Hridayesh |m 1154890228:Prakash, Hridayesh |p 9 |y j | ||
| 999 | |a KXP-PPN1694969649 |e 3627121791 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium","title":"Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium"}],"person":[{"family":"Nadella","given":"Vinod","roleDisplay":"VerfasserIn","display":"Nadella, Vinod","role":"aut"},{"family":"Prakash","given":"Hridayesh","roleDisplay":"VerfasserIn","display":"Prakash, Hridayesh","role":"aut"}],"titleAlt":[{"title":"Low dose radiation primed iNOS+M1macrophages modulate angiogenic programming of tumor derived endothelium"}],"note":["Gesehen am 20.04.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1694969649","language":["eng"],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":" 23 July 2018"}],"id":{"eki":["1694969649"],"doi":["10.1002/mc.22879"]},"name":{"displayForm":["Vinod Nadella, Sandhya Singh, Aklank Jain, Manju Jain, Karen M. Vasquez, Ashok Sharma, Pranay Tanwar, Goura Kishore Rath, Hridayesh Prakash"]},"physDesc":[{"extent":"8 S."}],"relHost":[{"id":{"issn":["1098-2744"],"zdb":["2001984-1"],"doi":["10.1002/(ISSN)1098-2744"],"eki":["320416364"]},"origin":[{"publisherPlace":"New York, NY","publisher":"Wiley Interscience","dateIssuedKey":"1988","dateIssuedDisp":"1988-"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Molecular carcinogenesis","title":"Molecular carcinogenesis"}],"part":{"volume":"57","text":"57(2018), 11, Seite 1664-1671","extent":"8","year":"2018","pages":"1664-1671","issue":"11"},"pubHistory":["1.1988 -"],"language":["eng"],"recId":"320416364","note":["Gesehen am 27.02.08"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endotheliumMolecular carcinogenesis"}]} | ||
| SRT | |a NADELLAVINLOWDOSERAD2320 | ||