Cancer susceptibility of beta HPV49 E6 and E7 transgenic mice to 4-nitroquinoline 1-oxide treatment correlates with mutational signatures of tobacco exposure
We have previously showed that a transgenic (Tg) mouse model with cytokeratin 14 promoter (K14)-driven expression of E6 and E7 from beta-3 HPV49 in the basal layer of the epidermis and of the mucosal epithelia of the digestive tract (K14 HPV49 E6/E7 Tg mice) are highly susceptible to upper digestive...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 September 2019
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| In: |
Virology
Year: 2019, Jahrgang: 538, Pages: 53-60 |
| ISSN: | 1096-0341 |
| DOI: | 10.1016/j.virol.2019.09.010 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.virol.2019.09.010 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0042682219302752 
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| Verfasserangaben: | Daniele Viarisio, Alexis Robitaille, Karin Müller-Decker, Christa Flechtenmacher, Lutz Gissmann, Massimo Tommasino |
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| 245 | 1 | 0 | |a Cancer susceptibility of beta HPV49 E6 and E7 transgenic mice to 4-nitroquinoline 1-oxide treatment correlates with mutational signatures of tobacco exposure |c Daniele Viarisio, Alexis Robitaille, Karin Müller-Decker, Christa Flechtenmacher, Lutz Gissmann, Massimo Tommasino |
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| 520 | |a We have previously showed that a transgenic (Tg) mouse model with cytokeratin 14 promoter (K14)-driven expression of E6 and E7 from beta-3 HPV49 in the basal layer of the epidermis and of the mucosal epithelia of the digestive tract (K14 HPV49 E6/E7 Tg mice) are highly susceptible to upper digestive tract carcinogenesis upon exposure to 4-nitroquinoline 1-oxide (4NQO). Using whole-exome sequencing, we show that in K14 HPV49 E6/E7 Tg mice, development of 4NQO-induced cancers tightly correlates with the accumulation of somatic mutations in cancer-related genes. The mutational signature in 4NQO-treated mice was similar to the signature observed in humans exposed to tobacco smoking and tobacco chewing. Similar results were obtained with K14 Tg animals expressing mucosal high-risk HPV16 E6 and E7 oncogenes. Thus, beta-3 HPV49 share some functional similarities with HPV16 in Tg animals. | ||
| 650 | 4 | |a 4-Nitroquinoline 1-oxide | |
| 650 | 4 | |a Beta HPV types | |
| 650 | 4 | |a Mutational signatures of tobacco exposure | |
| 650 | 4 | |a Upper-digestive tract cancer | |
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| 700 | 1 | |a Müller-Decker, Karin |e VerfasserIn |0 (DE-588)1084651351 |0 (DE-627)848630556 |0 (DE-576)169302431 |4 aut | |
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