Prevalence and prognostic impact of diabetes in takotsubo syndrome: insights from the international, multicenter GEIST registry
OBJECTIVE: In view of low prevalence rates, diabetes is discussed as a protective factor for the occurrence of Takotsubo syndrome (TTS). Furthermore, it was associated with improved outcome in a small single-center analysis. Therefore, this study assessed the prevalence and prognostic relevance of c...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
|
| In: |
Diabetes care
Year: 2018, Jahrgang: 41, Heft: 5, Pages: 1084-1088 |
| ISSN: | 1935-5548 |
| DOI: | 10.2337/dc17-2609 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2337/dc17-2609 Verlag, lizenzpflichtig, Volltext: https://care.diabetesjournals.org/content/41/5/1084.long 
|
| Verfasserangaben: | Thomas Stiermaier, Francesco Santoro, Ibrahim El-Battrawy, Christian Möller, Tobias Graf, Giuseppina Novo, Andrea Santangelo, Enrica Mariano, Francesco Romeo, Pasquale Caldarola, Mario Fanelli, Holger Thiele, Natale Daniele Brunetti, Ibrahim Akin and Ingo Eitel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1695253884 | ||
| 003 | DE-627 | ||
| 005 | 20220818045138.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200421s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2337/dc17-2609 |2 doi | |
| 035 | |a (DE-627)1695253884 | ||
| 035 | |a (DE-599)KXP1695253884 | ||
| 035 | |a (OCoLC)1341315782 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Stiermaier, Thomas |e VerfasserIn |0 (DE-588)1208702858 |0 (DE-627)1695253981 |4 aut | |
| 245 | 1 | 0 | |a Prevalence and prognostic impact of diabetes in takotsubo syndrome |b insights from the international, multicenter GEIST registry |c Thomas Stiermaier, Francesco Santoro, Ibrahim El-Battrawy, Christian Möller, Tobias Graf, Giuseppina Novo, Andrea Santangelo, Enrica Mariano, Francesco Romeo, Pasquale Caldarola, Mario Fanelli, Holger Thiele, Natale Daniele Brunetti, Ibrahim Akin and Ingo Eitel |
| 264 | 1 | |c 2018 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.04.2020 | ||
| 520 | |a OBJECTIVE: In view of low prevalence rates, diabetes is discussed as a protective factor for the occurrence of Takotsubo syndrome (TTS). Furthermore, it was associated with improved outcome in a small single-center analysis. Therefore, this study assessed the prevalence and prognostic relevance of concomitant diabetes in TTS. - RESEARCH DESIGN AND METHODS: A total of 826 patients with TTS were enrolled in an international, multicenter, registry-based study (eight centers in Italy and Germany). All-cause mortality was compared between patients with diabetes and patients without diabetes, and the independent predictive value of diabetes was evaluated in multivariate regression analysis. - RESULTS: The prevalence of diabetes was 21.1% (n = 174). TTS patients with diabetes were older (P < 0.001), were more frequently male (P = 0.003), had a higher prevalence of hypertension (P < 0.001), physical triggers (P = 0.041), and typical apical ballooning (P = 0.010), had a lower left ventricular ejection fraction (P = 0.008), had a higher rate of pulmonary edema (P = 0.032), and had a longer hospital stay (P = 0.009). However, 28-day all-cause mortality did not differ between patients with diabetes and patients without diabetes (6.4% vs. 5.7%; hazard ratio [HR] 1.11 [95% CI 0.55-2.25]; P = 0.772). Longer-term follow-up after a median of 2.5 years revealed a significantly higher mortality among TTS patients with diabetes (31.4% vs. 16.5%; P < 0.001), and multivariate regression analysis identified diabetes as an independent predictor of adverse outcome (HR 1.66 [95% CI 1.16-2.39]; P = 0.006). - CONCLUSIONS: Diabetes is not uncommon in patients with TTS, is associated with increased longer-term mortality rates, and is an independent predictor of adverse outcome irrespective of additional risk factors. | ||
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Diabetes Mellitus | |
| 650 | 4 | |a Diabetic Cardiomyopathies | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Germany | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Italy | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Prevalence | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Registries | |
| 650 | 4 | |a Risk Factors | |
| 650 | 4 | |a Takotsubo Cardiomyopathy | |
| 700 | 1 | |a Santoro, Francesco |e VerfasserIn |4 aut | |
| 700 | 1 | |a El-Battrawy, Ibrahim |d 1987- |e VerfasserIn |0 (DE-588)1033436917 |0 (DE-627)741219549 |0 (DE-576)38084673X |4 aut | |
| 700 | 1 | |a Möller, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Graf, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Novo, Giuseppina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Santangelo, Andrea |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mariano, Enrica |e VerfasserIn |4 aut | |
| 700 | 1 | |a Romeo, Francesco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Caldarola, Pasquale |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fanelli, Mario |e VerfasserIn |4 aut | |
| 700 | 1 | |a Thiele, Holger |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brunetti, Natale Daniele |e VerfasserIn |4 aut | |
| 700 | 1 | |a Akın, Ibrahim |d 1978- |e VerfasserIn |0 (DE-588)132322293 |0 (DE-627)521039010 |0 (DE-576)299074366 |4 aut | |
| 700 | 1 | |a Eitel, Ingo |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diabetes care |d Alexandria, Va. : Assoc., 1978 |g 41(2018), 5, Seite 1084-1088 |h Online-Ressource |w (DE-627)302195602 |w (DE-600)1490520-6 |w (DE-576)081894910 |x 1935-5548 |7 nnas |a Prevalence and prognostic impact of diabetes in takotsubo syndrome insights from the international, multicenter GEIST registry |
| 773 | 1 | 8 | |g volume:41 |g year:2018 |g number:5 |g pages:1084-1088 |g extent:5 |a Prevalence and prognostic impact of diabetes in takotsubo syndrome insights from the international, multicenter GEIST registry |
| 856 | 4 | 0 | |u https://doi.org/10.2337/dc17-2609 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://care.diabetesjournals.org/content/41/5/1084.long |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200421 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 132322293 |a Akın, Ibrahim |m 132322293:Akın, Ibrahim |d 60000 |d 61000 |e 60000PA132322293 |e 61000PA132322293 |k 0/60000/ |k 1/60000/61000/ |p 14 | ||
| 998 | |g 1033436917 |a El-Battrawy, Ibrahim |m 1033436917:El-Battrawy, Ibrahim |d 60000 |d 61000 |e 60000PE1033436917 |e 61000PE1033436917 |k 0/60000/ |k 1/60000/61000/ |p 3 | ||
| 999 | |a KXP-PPN1695253884 |e 3627550285 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 21.04.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"title":[{"title_sort":"Prevalence and prognostic impact of diabetes in takotsubo syndrome","title":"Prevalence and prognostic impact of diabetes in takotsubo syndrome","subtitle":"insights from the international, multicenter GEIST registry"}],"relHost":[{"name":{"displayForm":["American Diabetes Association"]},"pubHistory":["1.1978 -"],"id":{"zdb":["1490520-6"],"eki":["302195602"],"issn":["1935-5548"]},"part":{"year":"2018","volume":"41","pages":"1084-1088","extent":"5","text":"41(2018), 5, Seite 1084-1088","issue":"5"},"origin":[{"publisher":"Assoc.","dateIssuedKey":"1978","publisherPlace":"Alexandria, Va.","dateIssuedDisp":"1978-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"note":["1 (1978)-22 (1999) und Artikel \"published ahead of print\" sind nur für Subscriber zugänglich","Gesehen am 21.01.22"],"title":[{"title_sort":"Diabetes care","title":"Diabetes care"}],"physDesc":[{"extent":"Online-Ressource"}],"recId":"302195602","disp":"Prevalence and prognostic impact of diabetes in takotsubo syndrome insights from the international, multicenter GEIST registryDiabetes care"}],"person":[{"family":"Stiermaier","role":"aut","given":"Thomas","display":"Stiermaier, Thomas"},{"family":"Santoro","role":"aut","given":"Francesco","display":"Santoro, Francesco"},{"family":"El-Battrawy","role":"aut","given":"Ibrahim","display":"El-Battrawy, Ibrahim"},{"family":"Möller","role":"aut","given":"Christian","display":"Möller, Christian"},{"given":"Tobias","role":"aut","family":"Graf","display":"Graf, Tobias"},{"display":"Novo, Giuseppina","family":"Novo","given":"Giuseppina","role":"aut"},{"family":"Santangelo","role":"aut","given":"Andrea","display":"Santangelo, Andrea"},{"display":"Mariano, Enrica","role":"aut","given":"Enrica","family":"Mariano"},{"given":"Francesco","role":"aut","family":"Romeo","display":"Romeo, Francesco"},{"family":"Caldarola","role":"aut","given":"Pasquale","display":"Caldarola, Pasquale"},{"display":"Fanelli, Mario","given":"Mario","role":"aut","family":"Fanelli"},{"display":"Thiele, Holger","family":"Thiele","given":"Holger","role":"aut"},{"given":"Natale Daniele","role":"aut","family":"Brunetti","display":"Brunetti, Natale Daniele"},{"display":"Akın, Ibrahim","family":"Akın","role":"aut","given":"Ibrahim"},{"display":"Eitel, Ingo","given":"Ingo","role":"aut","family":"Eitel"}],"origin":[{"dateIssuedDisp":"2018","dateIssuedKey":"2018"}],"physDesc":[{"extent":"5 S."}],"recId":"1695253884","id":{"doi":["10.2337/dc17-2609"],"eki":["1695253884"]},"name":{"displayForm":["Thomas Stiermaier, Francesco Santoro, Ibrahim El-Battrawy, Christian Möller, Tobias Graf, Giuseppina Novo, Andrea Santangelo, Enrica Mariano, Francesco Romeo, Pasquale Caldarola, Mario Fanelli, Holger Thiele, Natale Daniele Brunetti, Ibrahim Akin and Ingo Eitel"]}} | ||
| SRT | |a STIERMAIERPREVALENCE2018 | ||