Protective actions of anserine under diabetic conditions
Background/Aims: In rodents, carnosine treatment improves diabetic nephropathy, whereas little is known about the role and function of anserine, the methylated form of carnosine. Methods: Antioxidant activity was measured by oxygen radical absorbance capacity and oxygen stress response in human rena...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 September 2018
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| In: |
International journal of molecular sciences
Year: 2018, Jahrgang: 19, Heft: 9 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms19092751 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms19092751 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/19/9/2751 
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| Verfasserangaben: | Verena Peters, Vittorio Calabrese, Elisabete Forsberg, Nadine Volk, Thomas Fleming, Hans Baelde, Tim Weigand, Christian Thiel, Angela Trovato, Maria Scuto, Sergio Modafferi and Claus Peter Schmitt |
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| 245 | 1 | 0 | |a Protective actions of anserine under diabetic conditions |c Verena Peters, Vittorio Calabrese, Elisabete Forsberg, Nadine Volk, Thomas Fleming, Hans Baelde, Tim Weigand, Christian Thiel, Angela Trovato, Maria Scuto, Sergio Modafferi and Claus Peter Schmitt |
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| 520 | |a Background/Aims: In rodents, carnosine treatment improves diabetic nephropathy, whereas little is known about the role and function of anserine, the methylated form of carnosine. Methods: Antioxidant activity was measured by oxygen radical absorbance capacity and oxygen stress response in human renal tubular cells (HK-2) by RT-PCR and Western-Immunoblotting. In wildtype (WT) and diabetic mice (db/db), the effect of short-term anserine treatment on blood glucose, proteinuria and vascular permeability was measured. Results: Anserine has a higher antioxidant capacity compared to carnosine (p < 0.001). In tubular cells (HK-2) stressed with 25 mM glucose or 20-100 µM hydrogen peroxide, anserine but not carnosine, increased intracellular heat shock protein (Hsp70) mRNA and protein levels. In HK-2 cells stressed with glucose, co-incubation with anserine also increased hemeoxygenase (HO-1) protein and reduced total protein carbonylation, but had no effect on cellular sirtuin-1 and thioredoxin protein concentrations. Three intravenous anserine injections every 48 h in 12-week-old db/db mice, improved blood glucose by one fifth, vascular permeability by one third, and halved proteinuria (all p < 0.05). Conclusion: Anserine is a potent antioxidant and activates the intracellular Hsp70/HO-1 defense system under oxidative and glycative stress. Short-term anserine treatment in diabetic mice improves glucose homeostasis and nephropathy. | ||
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