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Ex situ liver machine perfusion as an emerging graft protective strategy in clinical liver transplantation: the dawn of a new era

The disparity between the number of available donor livers and patients awaiting a liver transplant has led transplant centers to accept suboptimal livers. There has been no universally accepted tool to predict the posttransplant function of these organs to safely increase the donor pool, protect th...

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Main Authors: Nickkholgh, Arash (Author) , Nikdad, Mohammadsadegh (Author) , Shafie, Saeed (Author) , Abbasi Dezfouli, Sepehr (Author) , Mehrabi, Arianeb (Author) , Eason, James D. (Author) , Mas, Valeria R. (Author) , Maluf, Daniel G. (Author)
Format: Article (Journal)
Language:English
Published: October 2019
In: Transplantation
Year: 2019, Volume: 103, Issue: 10, Pages: 2003-2011
ISSN:1534-6080
DOI:10.1097/TP.0000000000002772
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/TP.0000000000002772
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/transplantjournal/Fulltext/2019/10000/Ex_Situ_Liver_Machine_Perfusion_as_an_Emerging.14.aspx
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Author Notes:Arash Nickkholgh, Mohammadsadegh Nikdad, Saeed Shafie, Sepehr Abbasi Dezfouli, Arianeb Mehrabi, James D. Eason, Valeria R. Mas, and Daniel G. Maluf
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Summary:The disparity between the number of available donor livers and patients awaiting a liver transplant has led transplant centers to accept suboptimal livers. There has been no universally accepted tool to predict the posttransplant function of these organs to safely increase the donor pool, protect these livers against ischemia-reperfusion injury, or improve their quality before implantation. Ex situ liver machine preservation has emerged as a promising novel graft protective strategy in the field of liver transplantation, with remarkable ongoing research and evolving clinical trials within Europe and the United States. This technology has been shown to be safe and feasible in the clinical liver transplantation field, has shown to reduce liver ischemia-reperfusion injury, and has shown to decrease the graft discard rate compared with conventional static cold storage. This review focuses on the current status of ex situ machine preservation in clinical liver transplantation, describing the most important technical aspects with the emphasis on the findings of the most recent clinical studies.
Item Description:Gesehen am 21.04.2020
Physical Description:Online Resource
ISSN:1534-6080
DOI:10.1097/TP.0000000000002772

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