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Missing elimination via membrane vesicle shedding contributes to the diminished calcium sensitivity of listeriolysin O

The lytic capacity of cholesterol-dependent cytolysins is enhanced in the extracellular calcium-free environment through a combination of limited membrane repair and diminished membrane toxin removal. For a typical neurotoxin of the group, pneumolysin, this effect has already been observed at reduce...

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Bibliographic Details
Main Authors: Maurer, Jana (Author) , Hupp, Sabrina (Author) , Pillich, Helena (Author) , Mitchell, Timothy J. (Author) , Chakraborty, Trinad (Author) , Iliev, Asparouh I. (Author)
Format: Article (Journal)
Language:English
Published: 26 October 2018
In: Scientific reports
Year: 2018, Volume: 8, Pages: 1-9
ISSN:2045-2322
DOI:10.1038/s41598-018-34031-4
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41598-018-34031-4
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41598-018-34031-4
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Author Notes:Jana Maurer, Sabrina Hupp, Helena Pillich, Timothy J. Mitchell, Trinad Chakraborty & Asparouh I. Iliev
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Summary:The lytic capacity of cholesterol-dependent cytolysins is enhanced in the extracellular calcium-free environment through a combination of limited membrane repair and diminished membrane toxin removal. For a typical neurotoxin of the group, pneumolysin, this effect has already been observed at reduced (1 mM) calcium conditions, which are pathophysiologically relevant. Here, we tested another neurotoxin of the group, listeriolysin O from L. monocytogenes, active in the primary vacuole after bacterium phagocytosis in host cells.
Item Description:Gesehen am 21.04.2020
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-018-34031-4

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