Complete and durable remission of human epidermal growth factor receptor 2-positive metastatic urothelial carcinoma following third-line treatment with trastuzumab and gemcitabine
Urothelial carcinoma (UC) is one of the most common cancers and survival rates are low in metastatic disease with currently established first-line platinum-based chemotherapies. Unlike in many other cancers, no clinically established molecular targeted therapies exist for the treatment of this malig...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2018
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| In: |
Urologia internationalis
Year: 2018, Volume: 100, Issue: 1, Pages: 122-125 |
| ISSN: | 1423-0399 |
| DOI: | 10.1159/000443280 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000443280 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/443280 
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| Author Notes: | Felix Wezel, Philipp Erben, Timo Gaiser, Johannes Budjan, Jost von Hardenberg, Maurice Stephan Michel, Christian Bolenz |
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| 520 | |a Urothelial carcinoma (UC) is one of the most common cancers and survival rates are low in metastatic disease with currently established first-line platinum-based chemotherapies. Unlike in many other cancers, no clinically established molecular targeted therapies exist for the treatment of this malignancy. Here we present a case of complete tumor remission following third-line treatment with trastuzumab and gemcitabine in a patient with human epidermal growth factor receptor 2 (HER2)-positive UC after progression under cisplatin and vinflunine chemotherapies. This case shows the potential significance of anti-HER2 therapy in selected patients with molecularly characterized UC. Clinical trials so far show inconclusive outcomes of anti-HER2 therapies in UC, indicating further need for both basic research and clinical studies for the identification of resistance factors and improved patient selection. | ||
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