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EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

Eps15-homology domain containing protein 2 (EHD2) is a dynamin-related ATPase located at the neck of caveolae, but its physiological function has remained unclear. Here, we found that global genetic ablation of EHD2 in mice leads to increased lipid droplet size in fat tissue. This organismic phenoty...

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Main Authors: Matthäus, Claudia (Author) , Lahmann, Ines (Author) , Kunz, Séverine (Author) , Jonas, Wenke (Author) , Melo, Arthur Alves (Author) , Lehmann, Martin (Author) , Larsson, Elin (Author) , Lundmark, Richard (Author) , Kern, Matthias (Author) , Blüher, Matthias (Author) , Olschowski, Hannah (Author) , Kompa, Julian (Author) , Brügger, Britta (Author) , Müller, Dominik N. (Author) , Haucke, Volker (Author) , Schürmann, Annette (Author) , Birchmeier, Carmen (Author) , Daumke, Oliver (Author)
Format: Article (Journal)
Language:English
Published: March 31, 2020
In: Proceedings of the National Academy of Sciences of the United States of America
Year: 2020, Volume: 117, Issue: 13, Pages: 7471-7481
ISSN:1091-6490
DOI:10.1073/pnas.1918415117
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.1918415117
Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/content/117/13/7471
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Author Notes:Claudia Matthaeus, Ines Lahmann, Séverine Kunz, Wenke Jonas, Arthur Alves Melo, Martin Lehmann, Elin Larsson, Richard Lundmark, Matthias Kern, Matthias Blüher, Hannah Olschowski, Julian Kompa, Britta Brügger, Dominik N. Müller, Volker Haucke, Annette Schürmann, Carmen Birchmeier, and Oliver Daumke

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