Mapping prostate cancer lesions before and after unsuccessful salvage lymph node dissection using repeat PSMA PET
Introduction: The aim of this study was to analyze patterns of persistent versus recurrent or new PET lesions in a selected patient cohort with PSA persistence following salvage lymph node dissection (SLND) and pre/post procedure prostate-specific membrane antigen ligand positron emission tomography...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2020
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| In: |
Journal of nuclear medicine
Year: 2019, Volume: 61, Issue: 7, Pages: 1037-1042 |
| ISSN: | 2159-662X |
| DOI: | 10.2967/jnumed.119.235374 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2967/jnumed.119.235374 Verlag, lizenzpflichtig, Volltext: http://jnm.snmjournals.org/content/early/2019/12/03/jnumed.119.235374 
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| Author Notes: | Andrea Farolfi, Harun Ilhan, Andrei Gafita, Jeremie Calais, Francesco Barbato, Manuel Weber, Ali Afshar-Oromieh, Fabian Spohn, Axel Wetter, Christoph Rischpler, Boris Hadaschik, Davide Pianori, Stefano Fanti, Uwe Haberkorn, Matthias Eiber, Ken Herrmann, and Wolfgang Peter Fendler |
MARC
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| 245 | 1 | 0 | |a Mapping prostate cancer lesions before and after unsuccessful salvage lymph node dissection using repeat PSMA PET |c Andrea Farolfi, Harun Ilhan, Andrei Gafita, Jeremie Calais, Francesco Barbato, Manuel Weber, Ali Afshar-Oromieh, Fabian Spohn, Axel Wetter, Christoph Rischpler, Boris Hadaschik, Davide Pianori, Stefano Fanti, Uwe Haberkorn, Matthias Eiber, Ken Herrmann, and Wolfgang Peter Fendler |
| 246 | 3 | 3 | |a Mapping prostate cancer lesions pre/post unsuccessful salvage lymph node dissection using repeat PSMA-PET |
| 264 | 1 | |c 2020 | |
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| 500 | |a Published online Dec. 5, 2019 | ||
| 500 | |a Gesehen am 17.09.2020 | ||
| 520 | |a Introduction: The aim of this study was to analyze patterns of persistent versus recurrent or new PET lesions in a selected patient cohort with PSA persistence following salvage lymph node dissection (SLND) and pre/post procedure prostate-specific membrane antigen ligand positron emission tomography (PSMA-PET). Material and Methods: 16 patients were included in this multicenter study. Inclusion criteria were: a) PSMA-PET performed for biochemical recurrence before SLND (pre-SLND PET) and b) repeat PSMA-PET performed for persistently elevated PSA level (≥0.1 ng/mL) ≥6 weeks after SLND (post-SLND PET). Image analysis was performed by three independent nuclear medicine physicians applying the molecular imaging TNM system PROMISE. Lesions were confirmed by histopathology, presence on correlative CT/MRI/bone scan or PSA response after focal therapy. Results: post-SLND PET identified PCa-lesions in 88% (14/16) of patients with PSA persistence after SLND. Median PSA was 1.2 ng/mL (IQR, 0.6-2.8 ng/mL). Disease was confined to the pelvis in 56% of patients (9/16) and most of these men had common iliac (6/16, 38%) and internal iliac lymph node metastases (6/16, 38%). Extrapelvic disease was detected in 31% of patients (5/16). In pre- and post-SLND PET comparison, 10/16 had at least one lesion already detected at baseline (63% PET persistence); 4/16 had new lesions only (25% PET recurrence); 2 had no disease on post-SLND PET. All validated regions (11 regions in 9 patients) were true positive. 9/14 (64%) patients underwent repeat local therapies after SLND (7/14 radiotherapy, 2/14 surgery). Conclusion: SLND of pelvic nodal metastases was often not complete according to PSMA-PET. About two thirds of patients had PET positive nodal disease after SLND already seen on pre-SLND PSMA-PET. Notably, about one quarter of patients had new lesions, not detected by pre-surgical PSMA-PET. | ||
| 534 | |c 2019 | ||
| 650 | 4 | |a Genitourinary | |
| 650 | 4 | |a Oncology: GU | |
| 650 | 4 | |a PET/CT | |
| 650 | 4 | |a positron emission tomography (PET) | |
| 650 | 4 | |a prostate cancer | |
| 650 | 4 | |a PSA persistence | |
| 650 | 4 | |a PSMA | |
| 650 | 4 | |a salvage lymph node dissection | |
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| 700 | 1 | |a Gafita, Andrei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Calais, Jeremie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Barbato, Francesco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weber, Manuel |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Pianori, Davide |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fanti, Stefano |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Eiber, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herrmann, Ken |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fendler, Wolfgang Peter |e VerfasserIn |4 aut | |
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