STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles
The centrosome linker proteins C-Nap1, rootletin, and CEP68 connect the two centrosomes of a cell during interphase into one microtubule-organizing center. This coupling is important for cell migration, cilia formation, and timing of mitotic spindle formation. Very little is known about the structur...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 20, 2018
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| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2018, Jahrgang: 115, Heft: 10, Pages: E2246-E2253 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.1716840115 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.1716840115 Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/content/115/10/E2246 
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| Verfasserangaben: | Rifka Vlijm, Xue Li, Marko Panic, Diana Rüthnick, Shoji Hata, Frank Herrmannsdörfer, Thomas Kuner, Mike Heilemann, Johann Engelhardt, Stefan W. Hell, and Elmar Schiebel |
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| 245 | 1 | 0 | |a STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles |c Rifka Vlijm, Xue Li, Marko Panic, Diana Rüthnick, Shoji Hata, Frank Herrmannsdörfer, Thomas Kuner, Mike Heilemann, Johann Engelhardt, Stefan W. Hell, and Elmar Schiebel |
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| 520 | |a The centrosome linker proteins C-Nap1, rootletin, and CEP68 connect the two centrosomes of a cell during interphase into one microtubule-organizing center. This coupling is important for cell migration, cilia formation, and timing of mitotic spindle formation. Very little is known about the structure of the centrosome linker. Here, we used stimulated emission depletion (STED) microscopy to show that each C-Nap1 ring at the proximal end of the two centrioles organizes a rootletin ring and, in addition, multiple rootletin/CEP68 fibers. | ||
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