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2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.

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Bibliographische Detailangaben
Hauptverfasser: Trzaska, Carole (VerfasserIn) , Amand, Séverine (VerfasserIn) , Bailly, Christine (VerfasserIn) , Leroy, Catherine (VerfasserIn) , Marchand, Virginie (VerfasserIn) , Duvernois-Berthet, Evelyne (VerfasserIn) , Saliou, Jean-Michel (VerfasserIn) , Benhabiles, Hana (VerfasserIn) , Werkmeister, Elisabeth (VerfasserIn) , Chassat, Thierry (VerfasserIn) , Guilbert, Romain (VerfasserIn) , Hannebique, David (VerfasserIn) , Mouray, Anthony (VerfasserIn) , Copin, Marie-Christine (VerfasserIn) , Moreau, Pierre-Arthur (VerfasserIn) , Adriaenssens, Eric (VerfasserIn) , Kulozik, Andreas (VerfasserIn) , Westhof, Eric (VerfasserIn) , Tulasne, David (VerfasserIn) , Motorin, Yuri (VerfasserIn) , Rebuffat, Sylvie (VerfasserIn) , Lejeune, Fabrice (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [2020]
In: Nature Communications
Year: 2020, Jahrgang: 11
ISSN:2041-1723
DOI:10.1038/s41467-020-15140-z
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-15140-z
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-15140-z
Volltext
Verfasserangaben:Carole Trzaska, Séverine Amand, Christine Bailly, Catherine Leroy, Virginie Marchand, Evelyne Duvernois-Berthet, Jean-Michel Saliou, Hana Benhabiles, Elisabeth Werkmeister, Thierry Chassat, Romain Guilbert, David Hannebique, Anthony Mouray, Marie-Christine Copin, Pierre-Arthur Moreau, Eric Adriaenssens, Andreas Kulozik, Eric Westhof, David Tulasne, Yuri Motorin, Sylvie Rebuffat, Fabrice Lejeune

MARC

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