IL-10 inducible CD8+ regulatory T-cells are enriched in patients with multiple myeloma and impact the generation of antigen-specific T-cells
Tumor-mediated immunosuppression via regulatory T-cells is a key player among the various immune-escape mechanisms in multiple myeloma. We analyzed the generation, distribution, function and immunophenotype of CD8+CD28− regulatory T-cells in patients with multiple myeloma. Functionality of CD8+CD28−...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 August 2018
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| In: |
Cancer immunology immunotherapy
Year: 2018, Volume: 67, Issue: 11, Pages: 1695-1707 |
| ISSN: | 1432-0851 |
| DOI: | 10.1007/s00262-018-2230-0 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00262-018-2230-0 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00262-018-2230-0 
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| Author Notes: | Julian Plaumann, Melanie Engelhardt, Mohamed H. S. Awwad, Hakim Echchannaoui, Eva Amman, Marc S. Raab, Jens Hillengass, Niels Halama, Brigitte Neuber, Carsten Müller-Tidow, Hartmut Goldschmidt, Michael Hundemer |
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| 520 | |a Tumor-mediated immunosuppression via regulatory T-cells is a key player among the various immune-escape mechanisms in multiple myeloma. We analyzed the generation, distribution, function and immunophenotype of CD8+CD28− regulatory T-cells in patients with multiple myeloma. Functionality of CD8+CD28− T-cells was assessed by immunological assays using ex vivo generated antigen-specific T-cells from patients with plasma cell dyscrasias and healthy donors. Detailed analysis of distribution, immunophenotype and cytotoxic potential of CD8+CD28− T-cells was performed by flow cytometry and ELISA. | ||
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