Feasibility of cardiovascular magnetic resonance to detect oxygenation deficits in patients with multi-vessel coronary artery disease triggered by breathing maneuvers
BACKGROUND: Hyperventilation with a subsequent breath-hold has been successfully used as a non-pharmacological vasoactive stimulus to induce changes in myocardial oxygenation. The purpose of this pilot study was to assess if this maneuver is feasible in patients with multi-vessel coronary artery dis...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 May 2018
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| In: |
Journal of cardiovascular magnetic resonance
Year: 2018, Jahrgang: 20, Pages: 1-11 |
| ISSN: | 1532-429X |
| DOI: | 10.1186/s12968-018-0446-y |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12968-018-0446-y
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| Verfasserangaben: | Kady Fischer, Kyohei Yamaji, Silvia Luescher, Yasushi Ueki, Bernd Jung, Hendrik von Tengg-Kobligk, Stephan Windecker, Matthias G. Friedrich, Balthasar Eberle and Dominik P. Guensch |
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| 245 | 1 | 0 | |a Feasibility of cardiovascular magnetic resonance to detect oxygenation deficits in patients with multi-vessel coronary artery disease triggered by breathing maneuvers |c Kady Fischer, Kyohei Yamaji, Silvia Luescher, Yasushi Ueki, Bernd Jung, Hendrik von Tengg-Kobligk, Stephan Windecker, Matthias G. Friedrich, Balthasar Eberle and Dominik P. Guensch |
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| 520 | |a BACKGROUND: Hyperventilation with a subsequent breath-hold has been successfully used as a non-pharmacological vasoactive stimulus to induce changes in myocardial oxygenation. The purpose of this pilot study was to assess if this maneuver is feasible in patients with multi-vessel coronary artery disease (CAD), and if it is effective at detecting coronary artery stenosis > 50% determined by quantitative coronary angiography (QCA). - METHODS: Twenty-six patients with coronary artery stenosis (QCA > 50% diameter stenosis) underwent a contrast-free cardiovascular magnetic resonance (CMR) exam in the time interval between their primary coronary angiography and a subsequent percutaneous coronary intervention (PCI, n = 24) or coronary artery bypass (CABG, n = 2) revascularization procedure. The CMR exam involved standard function imaging, myocardial strain analysis, T2 mapping, native T1 mapping and oxygenation-sensitive CMR (OS-CMR) imaging. During OS-CMR, participants performed a paced hyperventilation for 60s followed by a breath-hold to induce a vasoactive stimulus. Ten healthy subjects underwent the CMR protocol as the control group. - RESULTS: All CAD patients completed the breathing maneuvers with an average breath-hold duration of 48 ± 23 s following hyperventilation and without any complications or adverse effects. In comparison to healthy subjects, CAD patients had a significantly attenuated global myocardial oxygenation response to both hyperventilation (- 9.6 ± 6.8% vs. -3.1 ± 6.5%, p = 0.012) and apnea (11.3 ± 6.1% vs. 2.1 ± 4.4%, p < 0.001). The breath-hold maneuver unmasked regional oxygenation differences in territories subtended by a stenotic coronary artery in comparison to remote territory within the same patient (0.5 ± 3.8 vs. 3.8 ± 5.3%, p = 0.011). - CONCLUSION: Breathing maneuvers in conjunction with OS-CMR are clinically feasible in CAD patients. Furthermore, OS-CMR demonstrates myocardial oxygenation abnormalities in regional myocardium related to CAD without the use of pharmacologic vasodilators or contrast agents. A larger trial appears warranted for a better understanding of its diagnostic utility. - TRIAL REGISTRATION: Clinical Trials Identifier: NCT02233634 , registered 8 September 2014. | ||
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a BOLD | |
| 650 | 4 | |a Breath Holding | |
| 650 | 4 | |a Breathing maneuvers | |
| 650 | 4 | |a Case-Control Studies | |
| 650 | 4 | |a Coronary Angiography | |
| 650 | 4 | |a Coronary artery disease | |
| 650 | 4 | |a Coronary Artery Disease | |
| 650 | 4 | |a Coronary Stenosis | |
| 650 | 4 | |a Feasibility Studies | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Hemoglobins | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Hypercapnia | |
| 650 | 4 | |a Hyperventilation | |
| 650 | 4 | |a Hypocapnia | |
| 650 | 4 | |a Magnetic Resonance Imaging, Cine | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Myocardium | |
| 650 | 4 | |a Oxygen | |
| 650 | 4 | |a Oxygenation-sensitive cardiovascular magnetic resonance | |
| 650 | 4 | |a Pilot Projects | |
| 650 | 4 | |a Predictive Value of Tests | |
| 650 | 4 | |a Respiratory Rate | |
| 650 | 4 | |a Vasodilation | |
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| 700 | 1 | |a Ueki, Yasushi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jung, Bernd |e VerfasserIn |4 aut | |
| 700 | 1 | |a von Tengg-Kobligk, Hendrik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Windecker, Stephan |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Eberle, Balthasar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Guensch, Dominik P. |e VerfasserIn |4 aut | |
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