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Impact of FDG-PET on the detection of patients with lung cancer at high risk for ILD

BACKGROUND/AIM: Idiopathic pulmonary fibrosis IPF is a type of interstitial lung disease (ILD) with poor prognosis. Lung cancer (LC) is a frequent complication in IPF, where all therapeutic options are potential triggers for acute exacerbation of IPF. - PATIENTS AND METHODS: Patients with 2-deoxy-2-...

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Main Authors: Flechsig, Paul (Author) , Hural, Olena (Author) , Kreuter, Michael (Author) , Eichhorn, Martin E. (Author) , Heußel, Gudula (Author) , Sachpekidis, Christos (Author) , Kauczor, Hans-Ulrich (Author) , Haberkorn, Uwe (Author) , Heußel, Claus Peter (Author) , Eichinger, Monika (Author)
Format: Article (Journal)
Language:English
Published: November 2018
In: In vivo
Year: 2018, Volume: 32, Issue: 6, Pages: 1457-1462
ISSN:1791-7549
DOI:10.21873/invivo.11399
Online Access:Verlag, Volltext: https://doi.org/10.21873/invivo.11399
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Author Notes:Paul Flechsig, Olena Hural, Michael Kreuter, Martin Eichhorn, Gudula HEUßEL, Christos Sachpekidis, Hans-Ulrich Kauczor, Uwe Haberkorn, Claus Peter Heussel and Monika Eichinger
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Summary:BACKGROUND/AIM: Idiopathic pulmonary fibrosis IPF is a type of interstitial lung disease (ILD) with poor prognosis. Lung cancer (LC) is a frequent complication in IPF, where all therapeutic options are potential triggers for acute exacerbation of IPF. - PATIENTS AND METHODS: Patients with 2-deoxy-2-fluoro-D-glucose-positron emission tomography/computer tomography (FDG-PET/CT) results before lobectomy for LC with and without (n=10 each) signs of ILD in initial imaging and after-care CT were retrospectively analyzed. FDG uptake was calculated as the maximum standardized uptake value (SUVmax) in the lung periphery divided by the SUVmax of the mediastinal blood pool (rSUVmax). Regional increase of fibrosis and ground-glass features in lobe-based CT analysis was used as standard reference. - RESULTS: Patients with LC with ILD presented a significantly higher rSUVmax of 0.57 compared to patients without ILD with rSUVmax 0.47 (p<0.001). - CONCLUSION: rSUVmax seems to be a valuable imaging surrogate in predicting patients with LC with increased risk for progressive ILD associated with thoracic surgery.
Item Description:Gesehen am 24.04.2020
Physical Description:Online Resource
ISSN:1791-7549
DOI:10.21873/invivo.11399

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