Depression and resting state heart rate variability in children and adolescents: a systematic review and meta-analysis
Among adults, depression is associated with reduced vagal activity, as indexed by high frequency heart rate variability [HF-HRV]), which correlates inversely with depression severity. Available evidence in depressed children and adolescents remains to be reviewed systematically. A search of the lite...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 April 2016
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| In: |
Clinical psychology review
Year: 2016, Volume: 46, Pages: 136-150 |
| ISSN: | 1873-7811 |
| DOI: | 10.1016/j.cpr.2016.04.013 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cpr.2016.04.013 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S027273581530088X 
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| Author Notes: | Julian Koenig, Andrew H. Kemp, Theodore P. Beauchaine, Julian F. Thayer, Michael Kaess |
| Summary: | Among adults, depression is associated with reduced vagal activity, as indexed by high frequency heart rate variability [HF-HRV]), which correlates inversely with depression severity. Available evidence in depressed children and adolescents remains to be reviewed systematically. A search of the literature was performed to identify studies reporting (i) HF-HRV in clinically depressed children/adolescents relative to controls (k=4, n=259) and (ii) the association between HF-HRV and depressive symptoms as measured by standardized psychometric instruments in children and adolescents (k=6, n=2625). Random-effects meta-analysis on group differences revealed significant effects that were associated with a moderate effect size (Hedges' g=−0.59; 95% CI [−1.05; −0.13]), indicating lower resting state HF-HRV among clinically depressed children/adolescents (n=99) compared to healthy controls (n=160), consistent with findings among adults. While no correlation between HF-HRV and depressive symptom severity was observed (r=−.041 [−0.143; 0.062]), these additional correlational findings are limited to non-clinical samples. Findings have important clinical implications including a potentially increased risk for future physical ill health and also the identification of potential new treatment targets in child and adolescent depression. |
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| Item Description: | Gesehen am 29.04.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1873-7811 |
| DOI: | 10.1016/j.cpr.2016.04.013 |