Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4
Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately responsible for these addictions are poorly understood. Here, we investigated the transcriptional dependencies of tra...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 September 2018
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| In: |
Nature medicine
Year: 2018, Jahrgang: 24, Heft: 10, Pages: 1599-1610 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/s41591-018-0158-8 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41591-018-0158-8 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41591-018-0158-8 
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| Verfasserangaben: | Francesca Zanconato, Giusy Battilana, Mattia Forcato, Letizia Filippi, Luca Azzolin, Andrea Manfrin, Erika Quaranta, Daniele Di Biagio, Gianluca Sigismondo, Vincenza Guzzardo, Pascale Lejeune, Bernard Haendler, Jeroen Krijgsveld, Matteo Fassan, Silvio Bicciato, Michelangelo Cordenonsi and Stefano Piccolo |
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| 520 | |a Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately responsible for these addictions are poorly understood. Here, we investigated the transcriptional dependencies of transformed cells to the transcription factors YAP and TAZ. | ||
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