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Cryptic insertion of MYC exons 2 and 3 into the immunoglobulin heavy chain locus detected by whole genome sequencing in a case of “MYC-negative” Burkitt lymphoma

The genetic hallmark of Burkitt lymphoma (BL) is a translocation juxtaposing the MYC-oncogene to one of the three immunoglobulin (IG) loci.[1][1] There is ongoing controversy whether IG- MYC negative “true” BL exist. Various studies have identified 2-22% of BL as “ MYC -negative”.[2][2]-[5

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Bibliographic Details
Main Authors: Wagener, Rabea (Author) , Toprak, Umut (Author) , Seufert, Julian (Author) , Schlesner, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Haematologica
Year: 2020, Volume: 105, Issue: 4, Pages: e202-e205
ISSN:1592-8721
DOI:10.3324/haematol.2018.208140
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2018.208140
Verlag, lizenzpflichtig, Volltext: http://www.haematologica.org/content/105/4/e202
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Author Notes:Rabea Wagener, Susanne Bens, Umut H. Toprak, Julian Seufert, Cristina López, Ingrid Scholz, Heidi Herbrueggen, Ilske Oschlies, Stephan Stilgenbauer, Matthias Schlesner, Wolfram Klapper, Birgit Burkhardt and Reiner Siebert
Description
Summary:The genetic hallmark of Burkitt lymphoma (BL) is a translocation juxtaposing the MYC-oncogene to one of the three immunoglobulin (IG) loci.[1][1] There is ongoing controversy whether IG- MYC negative “true” BL exist. Various studies have identified 2-22% of BL as “ MYC -negative”.[2][2]-[5
Item Description:Gesehen am 29.04.2020
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.2018.208140

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