Cryptic insertion of MYC exons 2 and 3 into the immunoglobulin heavy chain locus detected by whole genome sequencing in a case of “MYC-negative” Burkitt lymphoma
The genetic hallmark of Burkitt lymphoma (BL) is a translocation juxtaposing the MYC-oncogene to one of the three immunoglobulin (IG) loci.[1][1] There is ongoing controversy whether IG- MYC negative “true” BL exist. Various studies have identified 2-22% of BL as “ MYC -negative”.[2][2]-[5
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
|
| In: |
Haematologica
Year: 2020, Jahrgang: 105, Heft: 4, Pages: e202-e205 |
| ISSN: | 1592-8721 |
| DOI: | 10.3324/haematol.2018.208140 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2018.208140 Verlag, lizenzpflichtig, Volltext: http://www.haematologica.org/content/105/4/e202 
|
| Verfasserangaben: | Rabea Wagener, Susanne Bens, Umut H. Toprak, Julian Seufert, Cristina López, Ingrid Scholz, Heidi Herbrueggen, Ilske Oschlies, Stephan Stilgenbauer, Matthias Schlesner, Wolfram Klapper, Birgit Burkhardt and Reiner Siebert |
| Zusammenfassung: | The genetic hallmark of Burkitt lymphoma (BL) is a translocation juxtaposing the MYC-oncogene to one of the three immunoglobulin (IG) loci.[1][1] There is ongoing controversy whether IG- MYC negative “true” BL exist. Various studies have identified 2-22% of BL as “ MYC -negative”.[2][2]-[5 |
|---|---|
| Beschreibung: | Gesehen am 29.04.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1592-8721 |
| DOI: | 10.3324/haematol.2018.208140 |