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Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain.

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Bibliographische Detailangaben
Hauptverfasser: Hanebuth, Marie Anne (VerfasserIn) , Kityk, Roman (VerfasserIn) , Fries, Sandra J. (VerfasserIn) , Jain, Alok (VerfasserIn) , Kriel, Allison (VerfasserIn) , Albanese, Veronique (VerfasserIn) , Frickey, Tancred (VerfasserIn) , Peter, Christine (VerfasserIn) , Mayer, Matthias P. (VerfasserIn) , Frydman, Judith (VerfasserIn) , Deuerling, Elke (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 5 Dec 2016
In: Nature Communications
Year: 2016, Jahrgang: 7
ISSN:2041-1723
DOI:10.1038/ncomms13695
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms13695
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms13695
Volltext
Verfasserangaben:Marie A. Hanebuth, Roman Kityk, Sandra J. Fries, Alok Jain, Allison Kriel, Veronique Albanese, Tancred Frickey, Christine Peter, Matthias P. Mayer, Judith Frydman, Elke Deuerling

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