Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain.
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5 Dec 2016
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| In: |
Nature Communications
Year: 2016, Jahrgang: 7 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms13695 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms13695 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms13695 |
| Verfasserangaben: | Marie A. Hanebuth, Roman Kityk, Sandra J. Fries, Alok Jain, Allison Kriel, Veronique Albanese, Tancred Frickey, Christine Peter, Matthias P. Mayer, Judith Frydman, Elke Deuerling |
| Zusammenfassung: | The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain. |
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| Beschreibung: | Gesehen am 30.04.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms13695 |