Using the galectin-3 test to predict mortality in heart failure patients: a systematic review and meta-analysis

Aim: Galectin-3 (Gal-3) is a new biomarker for assessing prognosis of heart failure (HF) patients. This systemic review and meta-analysis aims to examine Gal-3’s ability in assessing prognosis of HF patients. Method: We searched MEDLINE and Embase up to November 2014. Test performance characteristic...

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Hauptverfasser: Chen, Yueh-Sheng (VerfasserIn) , Gi, Weng-Tein (VerfasserIn) , Liao, Tin-Yun (VerfasserIn) , Lee, Meng-Tse Gabriel (VerfasserIn) , Lee, Si-Huei (VerfasserIn) , Hsu, Wan-Ting (VerfasserIn) , Chang, Shy-Shin (VerfasserIn) , Lee, Chien-Chang (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 9 February 2016
In: Biomarkers in medicine
Year: 2016, Jahrgang: 10, Heft: 3, Pages: 329-342
ISSN:1752-0371
DOI:10.2217/bmm.15.121
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2217/bmm.15.121
Verlag, lizenzpflichtig, Volltext: https://www.futuremedicine.com/doi/10.2217/bmm.15.121
Volltext
Verfasserangaben:Yueh-Sheng Chen, Weng-Tein Gi, Tin-Yun Liao, Meng-Tse Gabriel Lee, Si-Huei Lee, Wan-Ting Hsu, Shy-Shin Chang and Chien-Chang Lee

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520 |a Aim: Galectin-3 (Gal-3) is a new biomarker for assessing prognosis of heart failure (HF) patients. This systemic review and meta-analysis aims to examine Gal-3’s ability in assessing prognosis of HF patients. Method: We searched MEDLINE and Embase up to November 2014. Test performance characteristics were summarized using forest plots and hierarchical summary receiver operating characteristic curves. Results: The diagnostic odds ratio of Gal-3 in predicting mortality in chronic HF patients was 2.36 (95% CI: 1.71-3.26) and 2.30 (95% CI: 1.76-3.01) in acute HF patients. Conclusion: Elevated levels of Gal-3 are associated with mortality in both acute and chronic HF patients. However, current evidence does not support sole use of Gal-3 for prognosis evaluation of HF patients. 
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