N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold
How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermol...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 Sep 2016
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| In: |
Nature Communications
Year: 2016, Jahrgang: 7 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms12870 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms12870 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms12870 
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| Verfasserangaben: | Andreas J.W. Hartel, Marius Glogger, Nicola G. Jones, Wasim Abuillan, Christopher Batram, Anne Hermann, Susanne F. Fenz, Motomu Tanaka, Markus Engstler |
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| 520 | |a How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermolecular interactions. | ||
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