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N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold

How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermol...

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Bibliographic Details
Main Authors: Hartel, Andreas J. W. (Author) , Glogger, Marius (Author) , Jones, Nicola G. (Author) , Abuillan, Wasim (Author) , Batram, Christopher (Author) , Hermann, Anne (Author) , Fenz, Susanne F. (Author) , Tanaka, Motomu (Author) , Engstler, Markus (Author)
Format: Article (Journal)
Language:English
Published: 19 Sep 2016
In: Nature Communications
Year: 2016, Volume: 7
ISSN:2041-1723
DOI:10.1038/ncomms12870
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms12870
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms12870
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Author Notes:Andreas J.W. Hartel, Marius Glogger, Nicola G. Jones, Wasim Abuillan, Christopher Batram, Anne Hermann, Susanne F. Fenz, Motomu Tanaka, Markus Engstler
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Summary:How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermolecular interactions.
Item Description:Gesehen am 30.04.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms12870

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