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Platelet derived growth factor BB: a “must-have” therapeutic target “redivivus” in ovarian cancer

Background: We aimed to validate PDGF-BB protein expression by RNAscope, a sensitive method for PDGF-BB mRNA evaluation on paraffin embedded (FFPE) specimens of ovarian tumors. Materials and Methods: Seventy-five FFPE ovarian cancer biopsies were assessed by immunohistochemistry followed by PDGF-BB...

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Main Authors: Cimpean, Anca Maria (Author) , Cobec, Ionut Marcel (Author) , Ceaușu, Raluca Amalia (Author) , Popescu, Roxana (Author) , Tudor, Anca (Author) , Raica, Marius (Author)
Format: Article (Journal)
Language:English
Published: September 22, 2016
In: Cancer genomics & proteomics
Year: 2016, Volume: 13, Issue: 6, Pages: 511-517
ISSN:1790-6245
Online Access:Verlag, lizenzpflichtig, Volltext: http://cgp.iiarjournals.org/content/13/6/511
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Author Notes:Anca Maria Cimpean, Ionut Marcel Cobec, Raluca Amalia Ceaușu, Roxana Popescu, Anca Tudor and Marius Raica

MARC

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520 |a Background: We aimed to validate PDGF-BB protein expression by RNAscope, a sensitive method for PDGF-BB mRNA evaluation on paraffin embedded (FFPE) specimens of ovarian tumors. Materials and Methods: Seventy-five FFPE ovarian cancer biopsies were assessed by immunohistochemistry followed by PDGF-BB mRNA RNAscope validation. Results and Conclusion: Dual PDGF-BB expression in tumor and stromal cells have been observed, being highly suggestive for PDGF-BB mediated stromal-tumor cells reciprocal interaction in ovarian cancer (p=0.008). It seems that the nuclear expression of the PDGF-BB represents a negative prognostic factor in ovarian tumors. Being a controversial issue in the literature, PDGF-BB nuclear expression detected by immunohistochemistry was validated by RNAscope in situ hybridization. More than 65% of cases had PDGF-BB mRNA amplification, confirming immunohistochemical results. We herein validated PDGF-BB as a potential therapeutic and prognostic tool of ovarian cancer aggressiveness. 
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