Cover Image

Higher social rejection sensitivity in opioid-dependent patients is related to smaller insula gray matter volume: a voxel-based morphometric study

Opioid-dependent patients are highly sensitized to negative social feedback, and increased social rejection sensitivity was linked to adverse treatment outcome, but its neurobiological underpinnings have not been understood yet. The present study investigated gray matter (GM) volume differences betw...

Full description

Saved in:
Bibliographic Details
Main Authors: Bach, Patrick (Author) , Frischknecht, Ulrich (Author) , Klinkowski, Svenja (Author) , Bungert, Melanie (Author) , Karl, Damian (Author) , Vollmert, Christian (Author) , Vollstädt-Klein, Sabine (Author) , Lis, Stefanie (Author) , Kiefer, Falk (Author) , Hermann, Derik (Author)
Format: Article (Journal)
Language:English
Published: 10 December 2019
In: Social cognitive and affective neuroscience
Year: 2019, Volume: 14, Issue: 11, Pages: 1187-1195
ISSN:1749-5024
DOI:10.1093/scan/nsz094
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/scan/nsz094
Verlag, kostenfrei, Volltext: https://academic.oup.com/scan/article/14/11/1187/5671637
Get full text
Author Notes:Patrick Bach, Ulrich Frischknecht, Svenja Klinkowski, Melanie Bungert, Damian Karl, Christian Vollmert, Sabine Vollstädt-Klein, Stefanie Lis, Falk Kiefer, and Derik Hermann

MARC

LEADER 00000naa a2200000 c 4500
001 1697252044
003 DE-627
005 20200505173723.0
007 cr uuu---uuuuu
008 200505s2019 xx |||||o 00| ||eng c
024 7 |a 10.1093/scan/nsz094  |2 doi 
035 |a (DE-627)1697252044 
035 |a (DE-599)KXP1697252044 
035 |a (OCoLC)1153266477 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Bach, Patrick  |d 1987-  |e VerfasserIn  |0 (DE-588)1129478726  |0 (DE-627)884082393  |0 (DE-576)486427145  |4 aut 
245 1 0 |a Higher social rejection sensitivity in opioid-dependent patients is related to smaller insula gray matter volume  |b a voxel-based morphometric study  |c Patrick Bach, Ulrich Frischknecht, Svenja Klinkowski, Melanie Bungert, Damian Karl, Christian Vollmert, Sabine Vollstädt-Klein, Stefanie Lis, Falk Kiefer, and Derik Hermann 
264 1 |c 10 December 2019 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 05.05.2020 
520 |a Opioid-dependent patients are highly sensitized to negative social feedback, and increased social rejection sensitivity was linked to adverse treatment outcome, but its neurobiological underpinnings have not been understood yet. The present study investigated gray matter (GM) volume differences between 19 opioid maintenance treatment (OMT) patients and 20 healthy controls using magnetic resonance imaging and voxel-based morphometry. Associations of GM volumes with subjective feelings of exclusion and inclusion during a social ostracism (Cyberball) paradigm, with rejection sensitivity, social interaction anxiety and social phobia were explored. OMT patients displayed smaller GM volume in the bilateral insula and inferior frontal gyri. Psychometric and task data showed that patients reported significantly higher rejection sensitivity, social anxiety and social phobia scores and felt more excluded and less included during the social ostracism paradigm. Smaller GM volume in the insula was associated with higher subjective exclusion, lower subjective inclusion and higher rejection sensitivity, social anxiety and social phobia scores. Findings indicate that structural deficits in emotion- and anxiety-processing brain regions in OMT patients are associated with increased social rejection sensitivity. As social rejection is a potential trigger for relapse, patients might benefit from therapeutic strategies that promote social integration. 
700 1 |a Frischknecht, Ulrich  |d 1981-  |e VerfasserIn  |0 (DE-588)1119366542  |0 (DE-627)872719456  |0 (DE-576)479860254  |4 aut 
700 1 |a Klinkowski, Svenja  |e VerfasserIn  |4 aut 
700 1 |a Bungert, Melanie  |d 1982-  |e VerfasserIn  |0 (DE-588)1103058037  |0 (DE-627)860676900  |0 (DE-576)470470062  |4 aut 
700 1 |a Karl, Damian  |e VerfasserIn  |0 (DE-588)1202989608  |0 (DE-627)1687632413  |4 aut 
700 1 |a Vollmert, Christian  |d 1974-  |e VerfasserIn  |0 (DE-588)128554088  |0 (DE-627)374717699  |0 (DE-576)297211129  |4 aut 
700 1 |a Vollstädt-Klein, Sabine  |d 1973-  |e VerfasserIn  |0 (DE-588)128572744  |0 (DE-627)376206330  |0 (DE-576)188335935  |4 aut 
700 1 |a Lis, Stefanie  |d 1963-  |e VerfasserIn  |0 (DE-588)123104297  |0 (DE-627)08234969X  |0 (DE-576)293557675  |4 aut 
700 1 |a Kiefer, Falk  |d 1969-  |e VerfasserIn  |0 (DE-588)140919635  |0 (DE-627)703829033  |0 (DE-576)176310339  |4 aut 
700 1 |a Hermann, Derik  |d 1972-  |e VerfasserIn  |0 (DE-588)121855139  |0 (DE-627)705679047  |0 (DE-576)292920490  |4 aut 
773 0 8 |i Enthalten in  |t Social cognitive and affective neuroscience  |d Oxford : Oxford Univ. Press, 2006  |g 14(2019), 11, Seite 1187-1195  |h Online-Ressource  |w (DE-627)512664013  |w (DE-600)2236933-8  |w (DE-576)260775436  |x 1749-5024  |7 nnas  |a Higher social rejection sensitivity in opioid-dependent patients is related to smaller insula gray matter volume a voxel-based morphometric study 
773 1 8 |g volume:14  |g year:2019  |g number:11  |g pages:1187-1195  |g extent:9  |a Higher social rejection sensitivity in opioid-dependent patients is related to smaller insula gray matter volume a voxel-based morphometric study 
856 4 0 |u https://doi.org/10.1093/scan/nsz094  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://academic.oup.com/scan/article/14/11/1187/5671637  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20200505 
993 |a Article 
994 |a 2019 
998 |g 121855139  |a Hermann, Derik  |m 121855139:Hermann, Derik  |d 60000  |e 60000PH121855139  |k 0/60000/  |p 10  |y j 
998 |g 140919635  |a Kiefer, Falk  |m 140919635:Kiefer, Falk  |d 60000  |e 60000PK140919635  |k 0/60000/  |p 9 
998 |g 123104297  |a Lis, Stefanie  |m 123104297:Lis, Stefanie  |d 60000  |e 60000PL123104297  |k 0/60000/  |p 8 
998 |g 128572744  |a Vollstädt-Klein, Sabine  |m 128572744:Vollstädt-Klein, Sabine  |d 60000  |e 60000PV128572744  |k 0/60000/  |p 7 
998 |g 128554088  |a Vollmert, Christian  |m 128554088:Vollmert, Christian  |d 60000  |e 60000PV128554088  |k 0/60000/  |p 6 
998 |g 1202989608  |a Karl, Damian  |m 1202989608:Karl, Damian  |d 60000  |e 60000PK1202989608  |k 0/60000/  |p 5 
998 |g 1103058037  |a Bungert, Melanie  |m 1103058037:Bungert, Melanie  |d 60000  |e 60000PB1103058037  |k 0/60000/  |p 4 
998 |g 1119366542  |a Frischknecht, Ulrich  |m 1119366542:Frischknecht, Ulrich  |d 60000  |e 60000PF1119366542  |k 0/60000/  |p 2 
998 |g 1129478726  |a Bach, Patrick  |m 1129478726:Bach, Patrick  |d 60000  |e 60000PB1129478726  |k 0/60000/  |p 1  |x j 
999 |a KXP-PPN1697252044  |e 3659115622 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["512664013"],"zdb":["2236933-8"],"issn":["1749-5024"]},"language":["eng"],"origin":[{"publisher":"Oxford Univ. Press","dateIssuedKey":"2006","publisherPlace":"Oxford","dateIssuedDisp":"2006-"}],"title":[{"subtitle":"SCAN","title":"Social cognitive and affective neuroscience","title_sort":"Social cognitive and affective neuroscience"}],"titleAlt":[{"title":"SCAN"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"14(2019), 11, Seite 1187-1195","pages":"1187-1195","volume":"14","issue":"11","extent":"9","year":"2019"},"disp":"Higher social rejection sensitivity in opioid-dependent patients is related to smaller insula gray matter volume a voxel-based morphometric studySocial cognitive and affective neuroscience","pubHistory":["1.2006 -"],"note":["Gesehen am 13.02.25"],"recId":"512664013"}],"physDesc":[{"extent":"9 S."}],"person":[{"role":"aut","family":"Bach","display":"Bach, Patrick","given":"Patrick"},{"family":"Frischknecht","display":"Frischknecht, Ulrich","given":"Ulrich","role":"aut"},{"given":"Svenja","display":"Klinkowski, Svenja","family":"Klinkowski","role":"aut"},{"role":"aut","given":"Melanie","display":"Bungert, Melanie","family":"Bungert"},{"role":"aut","given":"Damian","display":"Karl, Damian","family":"Karl"},{"role":"aut","display":"Vollmert, Christian","family":"Vollmert","given":"Christian"},{"role":"aut","given":"Sabine","family":"Vollstädt-Klein","display":"Vollstädt-Klein, Sabine"},{"display":"Lis, Stefanie","family":"Lis","given":"Stefanie","role":"aut"},{"role":"aut","display":"Kiefer, Falk","family":"Kiefer","given":"Falk"},{"role":"aut","family":"Hermann","display":"Hermann, Derik","given":"Derik"}],"title":[{"title":"Higher social rejection sensitivity in opioid-dependent patients is related to smaller insula gray matter volume","subtitle":"a voxel-based morphometric study","title_sort":"Higher social rejection sensitivity in opioid-dependent patients is related to smaller insula gray matter volume"}],"id":{"eki":["1697252044"],"doi":["10.1093/scan/nsz094"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"10 December 2019"}],"recId":"1697252044","note":["Gesehen am 05.05.2020"],"name":{"displayForm":["Patrick Bach, Ulrich Frischknecht, Svenja Klinkowski, Melanie Bungert, Damian Karl, Christian Vollmert, Sabine Vollstädt-Klein, Stefanie Lis, Falk Kiefer, and Derik Hermann"]}} 
SRT |a BACHPATRICHIGHERSOCI1020 

Similar Items