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Myocardial reverse remodeling after pressure unloading is associated with maintained cardiac mechanoenergetics in a rat model of left ventricular hypertrophy

Pressure unloading represents the only effective therapy in increased afterload-induced left ventricular hypertrophy (LVH) as it leads to myocardial reverse remodeling (reduction of increased left ventricular mass, attenuated myocardial fibrosis) and preserved cardiac function. However, the effect o...

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Hauptverfasser: Ruppert, Mihály (VerfasserIn) , Korkmaz-İçöz, Sevil (VerfasserIn) , Li, Shiliang (VerfasserIn) , Németh, Balázs Tamás (VerfasserIn) , Hegedűs, Péter (VerfasserIn) , Brlecic, Paige (VerfasserIn) , Mátyás, Csaba (VerfasserIn) , Zorn, Markus (VerfasserIn) , Merkely, Béla (VerfasserIn) , Karck, Matthias (VerfasserIn) , Radovits, Tamás (VerfasserIn) , Szabó, Gábor (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 Sep 2016
In: American journal of physiology. Heart and circulatory physiology
Year: 2016, Jahrgang: 311, Heft: 3, Pages: H592-H603
ISSN:1522-1539
DOI:10.1152/ajpheart.00085.2016
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpheart.00085.2016
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajpheart.00085.2016
Volltext
Verfasserangaben:Mihály Ruppert, Sevil Korkmaz-Icöz, Shiliang Li, Balázs Tamás Németh, Péter Hegedűs, Paige Brlecic, Csaba Mátyás, Markus Zorn, Béla Merkely, Matthias Karck, Tamás Radovits, and Gábor Szabó
Beschreibung
Zusammenfassung:Pressure unloading represents the only effective therapy in increased afterload-induced left ventricular hypertrophy (LVH) as it leads to myocardial reverse remodeling (reduction of increased left ventricular mass, attenuated myocardial fibrosis) and preserved cardiac function. However, the effect of myocardial reverse remodeling on cardiac mechanoenergetics has not been elucidated. Therefore, we aimed to provide a detailed hemodynamic characterization in a rat model of LVH undergoing pressure unloading.
Beschreibung:Gesehen am 06.05.2020
Beschreibung:Online Resource
ISSN:1522-1539
DOI:10.1152/ajpheart.00085.2016

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