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Cellular handling of protein aggregates by disaggregation machines

Both acute proteotoxic stresses that unfold proteins and expression of disease-causing mutant proteins that expose aggregation-prone regions can promote protein aggregation. Protein aggregates can interfere with cellular processes and deplete factors crucial for protein homeostasis. To cope with the...

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Hauptverfasser: Mogk, Axel (VerfasserIn) , Bukau, Bernd (VerfasserIn) , Kampinga, Harm H. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 30 January 2018
In: Molecular cell
Year: 2018, Jahrgang: 69, Heft: 2, Pages: 214-226
ISSN:1097-4164
DOI:10.1016/j.molcel.2018.01.004
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molcel.2018.01.004
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1097276518300042
Volltext
Verfasserangaben:Axel Mogk, Bernd Bukau, and Harm H. Kampinga

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