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Impact of apoptotic circulating tumor cells (aCTC) in metastatic breast cancer

While intact circulating tumor cells (iCTC) have independent negative prognostic impact on patients with metastatic breast cancer (MBC), the prognostic relevance of apoptotic CTC (aCTC) has not been validated in larger patient cohorts. This study assessed aCTC and iCTC statuses at baseline (CTCBL) a...

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Main Authors: Deutsch, Thomas M. (Author) , Riethdorf, Sabine (Author) , Nees, Juliane (Author) , Hartkopf, Andreas (Author) , Schönfisch, Birgitt (Author) , Domschke, Christoph (Author) , Sprick, Martin (Author) , Schütz, Florian (Author) , Brucker, Sara (Author) , Stefanovic, Stefan (Author) , Sohn, Christof (Author) , Pantel, Klaus (Author) , Trumpp, Andreas (Author) , Schneeweiss, Andreas (Author) , Wallwiener, Markus (Author)
Format: Article (Journal)
Language:English
Published: 1 October 2016
In: Breast cancer research and treatment
Year: 2016, Volume: 160, Issue: 2, Pages: 277-290
ISSN:1573-7217
DOI:10.1007/s10549-016-3997-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10549-016-3997-3
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Author Notes:Thomas M. Deutsch, Sabine Riethdorf, Juliane Nees, Andreas D. Hartkopf, Birgitt Schönfisch, Christoph Domschke, Martin R. Sprick, Florian Schütz, Sara Y. Brucker, Stefan Stefanovic, Christof Sohn, Klaus Pantel, Andreas Trumpp, Andreas Schneeweiss and Markus Wallwiener
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Summary:While intact circulating tumor cells (iCTC) have independent negative prognostic impact on patients with metastatic breast cancer (MBC), the prognostic relevance of apoptotic CTC (aCTC) has not been validated in larger patient cohorts. This study assessed aCTC and iCTC statuses at baseline (CTCBL) and CTC kinetics (CTCKIN) as changes from CTCBL to one completed treatment cycle for their utility in predicting response, progression-free survival (PFS), and overall survival (OS) in MBC.
Item Description:Gesehen am 07.05.2020
Physical Description:Online Resource
ISSN:1573-7217
DOI:10.1007/s10549-016-3997-3

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