Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure
Ischemia-reperfusion injury is a common pathological process in liver surgery and transplantation, and has considerable impact on the patient outcome and survival. Death receptors are important mediators of ischemia-reperfusion injury, notably the signaling pathways of the death receptor CD95 (Apo-1...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 January 2018
|
| In: |
Cell death & disease
Year: 2018, Volume: 9, Issue: 2 |
| ISSN: | 2041-4889 |
| DOI: | 10.1038/s41419-017-0150-0 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41419-017-0150-0 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41419-017-0150-0 
|
| Author Notes: | Mohammed Al-Saeedi, Niels Steinebrunner, Hassan Kudsi, Niels Halama, Carolin Mogler, Markus W. Büchler, Peter H. Krammer, Peter Schemmer and Martina Müller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1697701744 | ||
| 003 | DE-627 | ||
| 005 | 20230427190256.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200507s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41419-017-0150-0 |2 doi | |
| 035 | |a (DE-627)1697701744 | ||
| 035 | |a (DE-599)KXP1697701744 | ||
| 035 | |a (OCoLC)1341319298 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Saeedi, Mohammed al |d 1981- |e VerfasserIn |0 (DE-588)1046246933 |0 (DE-627)776004999 |0 (DE-576)399532498 |4 aut | |
| 245 | 1 | 0 | |a Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure |c Mohammed Al-Saeedi, Niels Steinebrunner, Hassan Kudsi, Niels Halama, Carolin Mogler, Markus W. Büchler, Peter H. Krammer, Peter Schemmer and Martina Müller |
| 264 | 1 | |c 26 January 2018 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.05.2020 | ||
| 520 | |a Ischemia-reperfusion injury is a common pathological process in liver surgery and transplantation, and has considerable impact on the patient outcome and survival. Death receptors are important mediators of ischemia-reperfusion injury, notably the signaling pathways of the death receptor CD95 (Apo-1/Fas) and its corresponding ligand CD95L. This study investigates, for the first time, whether the inhibition of CD95L protects the liver against ischemia-reperfusion injury. Warm ischemia was induced in the median and left liver lobes of C57BL/6 mice for 45 min. CD95Fc, a specific inhibitor of CD95L, was applied prior to ischemia. Hepatic injury was assessed via consecutive measurements of liver serum enzymes, histopathological assessment of apoptosis and necrosis and caspase assays at 3, 6, 12, 18 and 24 h after reperfusion. Serum levels of liver enzymes, as well as characteristic histopathological changes and caspase assays indicated pronounced features of apoptotic and necrotic liver damage 12 and 24 h after ischemia-reperfusion injury. Animals treated with the CD95L-blocker CD95Fc, exhibited a significant reduction in the level of serum liver enzymes and showed both decreased histopathological signs of parenchymal damage and decreased caspase activation. This study demonstrates that inhibition of CD95L with the CD95L-blocker CD95Fc, is effective in protecting mice from liver failure due to ischemia-reperfusion injury of the liver. CD95Fc could therefore emerge as a new pharmacological therapy for liver resection, transplantation surgery and acute liver failure. | ||
| 700 | 1 | |a Steinebrunner, Niels |d 1979- |e VerfasserIn |0 (DE-588)133209040 |0 (DE-627)538678356 |0 (DE-576)299695875 |4 aut | |
| 700 | 1 | |a Kudsi, Hassan |e VerfasserIn |0 (DE-588)1209714396 |0 (DE-627)1697698840 |4 aut | |
| 700 | 1 | |a Halama, Niels |d 1977- |e VerfasserIn |0 (DE-588)13087325X |0 (DE-627)507228723 |0 (DE-576)251045706 |4 aut | |
| 700 | 1 | |a Mogler, Carolin |d 1980- |e VerfasserIn |0 (DE-588)139825827 |0 (DE-627)613790766 |0 (DE-576)313435995 |4 aut | |
| 700 | 1 | |a Büchler, Markus W. |d 1955- |e VerfasserIn |0 (DE-588)120893339 |0 (DE-627)080952526 |0 (DE-576)292434146 |4 aut | |
| 700 | 1 | |a Krammer, Peter H. |d 1946- |e VerfasserIn |0 (DE-588)121766373 |0 (DE-627)081520255 |0 (DE-576)292873417 |4 aut | |
| 700 | 1 | |a Schemmer, Peter |d 1967- |e VerfasserIn |0 (DE-588)1022604244 |0 (DE-627)717006794 |0 (DE-576)365668230 |4 aut | |
| 700 | 1 | |a Müller, Martina |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell death & disease |d London [u.a.] : Nature Publishing Group, 2010 |g 9(2018,2) Artikel-Nummer 132, 9 Seiten |h Online-Ressource |w (DE-627)620145250 |w (DE-600)2541626-1 |w (DE-576)319429059 |x 2041-4889 |7 nnas |a Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure |
| 773 | 1 | 8 | |g volume:9 |g year:2018 |g number:2 |g extent:9 |a Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41419-017-0150-0 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41419-017-0150-0 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200507 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1022604244 |a Schemmer, Peter |m 1022604244:Schemmer, Peter |p 8 | ||
| 998 | |g 121766373 |a Krammer, Peter H. |m 121766373:Krammer, Peter H. |d 50000 |e 50000PK121766373 |k 0/50000/ |p 7 | ||
| 998 | |g 120893339 |a Büchler, Markus W. |m 120893339:Büchler, Markus W. |d 910000 |d 910200 |e 910000PB120893339 |e 910200PB120893339 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 139825827 |a Mogler, Carolin |m 139825827:Mogler, Carolin |p 5 | ||
| 998 | |g 13087325X |a Halama, Niels |m 13087325X:Halama, Niels |d 910000 |d 910100 |e 910000PH13087325X |e 910100PH13087325X |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1209714396 |a Kudsi, Hassan |m 1209714396:Kudsi, Hassan |p 3 | ||
| 998 | |g 133209040 |a Steinebrunner, Niels |m 133209040:Steinebrunner, Niels |d 910000 |d 910100 |e 910000PS133209040 |e 910100PS133209040 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1046246933 |a Saeedi, Mohammed al |m 1046246933:Saeedi, Mohammed al |d 910000 |d 910200 |e 910000PS1046246933 |e 910200PS1046246933 |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1697701744 |e 3662463016 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1697701744"],"doi":["10.1038/s41419-017-0150-0"]},"recId":"1697701744","name":{"displayForm":["Mohammed Al-Saeedi, Niels Steinebrunner, Hassan Kudsi, Niels Halama, Carolin Mogler, Markus W. Büchler, Peter H. Krammer, Peter Schemmer and Martina Müller"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"26 January 2018"}],"language":["eng"],"note":["Gesehen am 07.05.2020"],"person":[{"display":"Saeedi, Mohammed al","family":"Saeedi","role":"aut","given":"Mohammed al"},{"given":"Niels","display":"Steinebrunner, Niels","role":"aut","family":"Steinebrunner"},{"given":"Hassan","role":"aut","family":"Kudsi","display":"Kudsi, Hassan"},{"family":"Halama","role":"aut","display":"Halama, Niels","given":"Niels"},{"given":"Carolin","display":"Mogler, Carolin","role":"aut","family":"Mogler"},{"given":"Markus W.","display":"Büchler, Markus W.","role":"aut","family":"Büchler"},{"display":"Krammer, Peter H.","family":"Krammer","role":"aut","given":"Peter H."},{"given":"Peter","family":"Schemmer","role":"aut","display":"Schemmer, Peter"},{"display":"Müller, Martina","role":"aut","family":"Müller","given":"Martina"}],"relHost":[{"part":{"text":"9(2018,2) Artikel-Nummer 132, 9 Seiten","year":"2018","issue":"2","volume":"9","extent":"9"},"title":[{"title":"Cell death & disease","title_sort":"Cell death & disease"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"issn":["2041-4889"],"zdb":["2541626-1"],"eki":["620145250"]},"recId":"620145250","origin":[{"publisher":"Nature Publishing Group","dateIssuedKey":"2010","publisherPlace":"London [u.a.]","dateIssuedDisp":"2010-"}],"disp":"Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failureCell death & disease","language":["eng"],"pubHistory":["1.2010 -"],"titleAlt":[{"title":"Cell death and disease"}],"note":["Gesehen am 26.02.10"]}],"title":[{"title_sort":"Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure","title":"Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure"}],"physDesc":[{"extent":"9 S."}]} | ||
| SRT | |a SAEEDIMOHANEUTRALIZA2620 | ||