National practice patterns for clinical T1N0 Nasopharyngeal Cancer in the elderly: a national cancer data base analysis
Background: The standard of care for T1N0 nasopharyngeal cancer (NPC) is definitive radiation therapy (RT). However, practice patterns in the elderly may not necessarily follow national guidelines. Herein, we investigated national practice patterns for T1N0 NPC. Materials and Methods: The National C...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
|
| In: |
Anticancer research
Year: 2018, Volume: 38, Issue: 3, Pages: 1651-1657 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.12397 |
| Online Access: | Verlag, Volltext: https://doi.org/10.21873/anticanres.12397 Verlag: http://ar.iiarjournals.org/content/38/3/1651 
|
| Author Notes: | Carl M. Post, Chi Lin, Sebastian Adeberg, Mrigank Gupta, Weining Zhen and Vivek Verma |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1697761925 | ||
| 003 | DE-627 | ||
| 005 | 20220818080553.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200508s2018 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1697761925 | ||
| 035 | |a (DE-599)KXP1697761925 | ||
| 035 | |a (OCoLC)1341319394 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Post, Carl M. |e VerfasserIn |0 (DE-588)1163849960 |0 (DE-627)1028187327 |0 (DE-576)508252237 |4 aut | |
| 245 | 1 | 0 | |a National practice patterns for clinical T1N0 Nasopharyngeal Cancer in the elderly |b a national cancer data base analysis |c Carl M. Post, Chi Lin, Sebastian Adeberg, Mrigank Gupta, Weining Zhen and Vivek Verma |
| 264 | 1 | |c 2018 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.05.2020 | ||
| 520 | |a Background: The standard of care for T1N0 nasopharyngeal cancer (NPC) is definitive radiation therapy (RT). However, practice patterns in the elderly may not necessarily follow national guidelines. Herein, we investigated national practice patterns for T1N0 NPC. Materials and Methods: The National Cancer Data Base (NCDB) was queried for clinical T1N0 primary NPC cases (2004-2013) in patients ≥70 years old. Patient, tumor, and treatment parameters were extracted. Kaplan-Meier analysis was used to compare overall survival (OS) between patients receiving RT versus those under observation. Logistic regression was used to examine variables associated with receipt of RT. Cox proportional hazards modeling determined variables associated with OS. Landmark analysis of patients surviving 1 year or more was performed to assess survival differences between groups. Results: In total, data of 147 patients were analyzed. RT was delivered to 89 patients (61%), whereas 58 (39%) patients underwent observation. On multivariable analysis, older patients were less likely to receive RT (p=0.003), but there were no differences between groups in terms of Charlson-Deyo comorbidity index. Median and 5-year OS in patients receiving RT versus those under observation were 71 and 33 months, and 59% and 48% (p=0.011), respectively. For patients surviving 1 year or more (n=96), there was a strong trend showing that receipt of RT was associated with better median and 5-year OS. Conclusion: This National Data Base analysis shows that observation is relatively common for T1N0 NPC in the elderly, but is associated with poorer survival. | ||
| 650 | 4 | |a Nasopharyngeal cancer | |
| 650 | 4 | |a nasopharynx | |
| 650 | 4 | |a observation | |
| 650 | 4 | |a radiation therapy | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Adeberg, Sebastian |d 1984- |e VerfasserIn |0 (DE-588)1049743377 |0 (DE-627)782574467 |0 (DE-576)403727774 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |g 38(2018), 3, Seite 1651-1657 |h Online-Ressource |w (DE-627)387478493 |w (DE-600)2145376-7 |w (DE-576)358408717 |x 1791-7530 |7 nnas |a National practice patterns for clinical T1N0 Nasopharyngeal Cancer in the elderly a national cancer data base analysis |
| 773 | 1 | 8 | |g volume:38 |g year:2018 |g number:3 |g pages:1651-1657 |g extent:7 |a National practice patterns for clinical T1N0 Nasopharyngeal Cancer in the elderly a national cancer data base analysis |
| 856 | 4 | 0 | |u https://doi.org/10.21873/anticanres.12397 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://ar.iiarjournals.org/content/38/3/1651 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20200508 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1049743377 |a Adeberg, Sebastian |m 1049743377:Adeberg, Sebastian |d 910000 |d 911400 |e 910000PA1049743377 |e 911400PA1049743377 |k 0/910000/ |k 1/910000/911400/ |p 3 | ||
| 999 | |a KXP-PPN1697761925 |e 3663143759 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"7 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1791-7530"],"zdb":["2145376-7"],"eki":["387478493"]},"origin":[{"dateIssuedDisp":"2004-","dateIssuedKey":"2004","publisher":"International Institute of Anticancer Research","publisherPlace":"Kapandriti, Attiki, Greece"}],"name":{"displayForm":["International Institute of Anticancer Research"]},"part":{"extent":"7","text":"38(2018), 3, Seite 1651-1657","volume":"38","pages":"1651-1657","issue":"3","year":"2018"},"pubHistory":["Nachgewiesen 24.2004 -"],"recId":"387478493","language":["eng"],"note":["Gesehen am 26.02.13"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"National practice patterns for clinical T1N0 Nasopharyngeal Cancer in the elderly a national cancer data base analysisAnticancer research","title":[{"title_sort":"Anticancer research","subtitle":"international journal of cancer research and treatment","title":"Anticancer research"}]}],"origin":[{"dateIssuedDisp":"2018","dateIssuedKey":"2018"}],"id":{"eki":["1697761925"]},"name":{"displayForm":["Carl M. Post, Chi Lin, Sebastian Adeberg, Mrigank Gupta, Weining Zhen and Vivek Verma"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 08.05.2020"],"recId":"1697761925","language":["eng"],"title":[{"title_sort":"National practice patterns for clinical T1N0 Nasopharyngeal Cancer in the elderly","subtitle":"a national cancer data base analysis","title":"National practice patterns for clinical T1N0 Nasopharyngeal Cancer in the elderly"}],"person":[{"roleDisplay":"VerfasserIn","display":"Post, Carl M.","role":"aut","family":"Post","given":"Carl M."},{"given":"Sebastian","family":"Adeberg","role":"aut","display":"Adeberg, Sebastian","roleDisplay":"VerfasserIn"}]} | ||
| SRT | |a POSTCARLMANATIONALPR2018 | ||