Chemical derivatization and biofunctionalization of hydrogel nanomembranes for potential biomedical and biosensor applications
Poly(ethylene glycol) based hydrogel nanomembranes (PHMs) are demonstrated to be able to host protein-specific receptors, providing, at the same time, stable, protein-repelling matrices with a characteristic mesh size up to 7-8 nm. The membranes were prepared by crosslinking of amino- and epoxy-term...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[2016]
|
| In: |
Physical chemistry, chemical physics
Year: 2016, Jahrgang: 18, Heft: 17, Pages: 12035-12042 |
| ISSN: | 1463-9084 |
| DOI: | 10.1039/C5CP07840G |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C5CP07840G Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2016/cp/c5cp07840g 
|
| Verfasserangaben: | Musammir Khan, Swen Schuster and Michael Zharnikov |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 169782661X | ||
| 003 | DE-627 | ||
| 005 | 20230427123405.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200511s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1039/C5CP07840G |2 doi | |
| 035 | |a (DE-627)169782661X | ||
| 035 | |a (DE-599)KXP169782661X | ||
| 035 | |a (OCoLC)1341319704 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Khan, Musammir |e VerfasserIn |0 (DE-588)1209904950 |0 (DE-627)1697827330 |4 aut | |
| 245 | 1 | 0 | |a Chemical derivatization and biofunctionalization of hydrogel nanomembranes for potential biomedical and biosensor applications |c Musammir Khan, Swen Schuster and Michael Zharnikov |
| 264 | 1 | |c [2016] | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.05.2020 | ||
| 520 | |a Poly(ethylene glycol) based hydrogel nanomembranes (PHMs) are demonstrated to be able to host protein-specific receptors, providing, at the same time, stable, protein-repelling matrices with a characteristic mesh size up to 7-8 nm. The membranes were prepared by crosslinking of amino- and epoxy-terminated STAR-PEG precursors and maintained their hydrogel and protein-repelling properties even at a deviation of the precursor composition from the equilibrium value (1 : 1). The grafting density of the test avidin protein, specifically attached to the biotin moieties coupled to the free amine groups in the PHMs, varied from 0.45 × 1012 to 1.3 × 1012 proteins per cm2 within the sampling depth of the experiments (∼11.5 nm), depending on the precursor composition, whereas the analogous values for the non-specifically adsorbed proteins were lower by a factor of 4-5. The engineering of PHMs with biomolecule-specific receptors and their loading with biomolecules are of potential interest for sensor fabrication and biomedical applications, including tissue engineering and regenerative therapy. | ||
| 700 | 1 | |a Schuster, Swen |e VerfasserIn |0 (DE-588)1079361081 |0 (DE-627)840918267 |0 (DE-576)452395658 |4 aut | |
| 700 | 1 | |a Zharnikov, Michael |e VerfasserIn |0 (DE-588)1118537629 |0 (DE-627)872019810 |0 (DE-576)479525889 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Physical chemistry, chemical physics |d Cambridge : RSC Publ., 1999 |g 18(2016), 17, Seite 12035-12042 |h Online-Ressource |w (DE-627)270125175 |w (DE-600)1476244-4 |w (DE-576)080160328 |x 1463-9084 |7 nnas |a Chemical derivatization and biofunctionalization of hydrogel nanomembranes for potential biomedical and biosensor applications |
| 773 | 1 | 8 | |g volume:18 |g year:2016 |g number:17 |g pages:12035-12042 |g extent:8 |a Chemical derivatization and biofunctionalization of hydrogel nanomembranes for potential biomedical and biosensor applications |
| 856 | 4 | 0 | |u https://doi.org/10.1039/C5CP07840G |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://pubs.rsc.org/en/content/articlelanding/2016/cp/c5cp07840g |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200511 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1118537629 |a Zharnikov, Michael |m 1118537629:Zharnikov, Michael |d 120000 |d 120300 |e 120000PZ1118537629 |e 120300PZ1118537629 |k 0/120000/ |k 1/120000/120300/ |p 3 |y j | ||
| 998 | |g 1079361081 |a Schuster, Swen |m 1079361081:Schuster, Swen |p 2 | ||
| 998 | |g 1209904950 |a Khan, Musammir |m 1209904950:Khan, Musammir |p 1 |x j | ||
| 999 | |a KXP-PPN169782661X |e 3664525582 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"id":{"zdb":["1476244-4"],"issn":["1463-9084"],"eki":["270125175"]},"origin":[{"publisher":"RSC Publ.","dateIssuedKey":"1999","dateIssuedDisp":"1999-","publisherPlace":"Cambridge"}],"name":{"displayForm":["RSC, Royal Society of Chemistry"]},"recId":"270125175","disp":"Chemical derivatization and biofunctionalization of hydrogel nanomembranes for potential biomedical and biosensor applicationsPhysical chemistry, chemical physics","title":[{"subtitle":"PCCP ; a journal of European chemical societies","title":"Physical chemistry, chemical physics","title_sort":"Physical chemistry, chemical physics"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"display":"Royal Society of Chemistry","role":"isb"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"8","text":"18(2016), 17, Seite 12035-12042","volume":"18","pages":"12035-12042","year":"2016","issue":"17"},"titleAlt":[{"title":"PCCP"}],"note":["Gesehen am 20.02.24"],"pubHistory":["1.1999 -"]}],"note":["Gesehen am 11.05.2020"],"recId":"169782661X","name":{"displayForm":["Musammir Khan, Swen Schuster and Michael Zharnikov"]},"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"[2016]"}],"id":{"doi":["10.1039/C5CP07840G"],"eki":["169782661X"]},"language":["eng"],"physDesc":[{"extent":"8 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Chemical derivatization and biofunctionalization of hydrogel nanomembranes for potential biomedical and biosensor applications","title":"Chemical derivatization and biofunctionalization of hydrogel nanomembranes for potential biomedical and biosensor applications"}],"person":[{"display":"Khan, Musammir","given":"Musammir","role":"aut","family":"Khan"},{"display":"Schuster, Swen","family":"Schuster","role":"aut","given":"Swen"},{"role":"aut","given":"Michael","family":"Zharnikov","display":"Zharnikov, Michael"}]} | ||
| SRT | |a KHANMUSAMMCHEMICALDE2016 | ||