Oligometastatic gastroesophageal adenocarcinoma: molecular pathophysiology and current therapeutic approach

Gastric and esophageal cancers are dreaded malignancies, with a majority of patients presenting in either a locally advanced or metastatic state. Global incidences are rising and the overall prognosis remains poor. The concept of oligometastasis has been established for other tumor entities and is a...

Full description

Saved in:
Bibliographic Details
Main Authors: Jung, Jin-On (Author) , Nienhüser, Henrik (Author) , Schleußner, Nikolai (Author) , Schmidt, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 31 January 2020
In: International journal of molecular sciences
Year: 2020, Volume: 21, Issue: 3
ISSN:1422-0067
DOI:10.3390/ijms21030951
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms21030951
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/21/3/951
Get full text
Author Notes:Jin-On Jung, Henrik Nienhüser, Nikolai Schleussner and Thomas Schmidt

MARC

LEADER 00000caa a2200000 c 4500
001 1697871771
003 DE-627
005 20220818081827.0
007 cr uuu---uuuuu
008 200511s2020 xx |||||o 00| ||eng c
024 7 |a 10.3390/ijms21030951  |2 doi 
035 |a (DE-627)1697871771 
035 |a (DE-599)KXP1697871771 
035 |a (OCoLC)1341319506 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Jung, Jin-On  |d 1990-  |e VerfasserIn  |0 (DE-588)1190665913  |0 (DE-627)166922256X  |4 aut 
245 1 0 |a Oligometastatic gastroesophageal adenocarcinoma  |b molecular pathophysiology and current therapeutic approach  |c Jin-On Jung, Henrik Nienhüser, Nikolai Schleussner and Thomas Schmidt 
264 1 |c 31 January 2020 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 11.05.2020 
520 |a Gastric and esophageal cancers are dreaded malignancies, with a majority of patients presenting in either a locally advanced or metastatic state. Global incidences are rising and the overall prognosis remains poor. The concept of oligometastasis has been established for other tumor entities and is also proposed for upper gastrointestinal tract cancers. This review article explores metastasis mechanisms on the molecular level, specific to esophageal and gastric adenocarcinoma. Existing data and recent studies that deal with upper gastrointestinal tumors in the oligometastatic state are reviewed. Furthermore, current therapeutic targets in gastroesophageal cancers are presented and discussed. Finally, a perspective about future diagnostic and therapeutic strategies is given. 
650 4 |a adenocarcinoma 
650 4 |a esophageal cancer 
650 4 |a gastric cancer 
650 4 |a gastroesophageal 
650 4 |a immunotherapy 
650 4 |a metastatic mechanism 
650 4 |a oligometastasis 
650 4 |a surgical resection 
700 1 |a Nienhüser, Henrik  |d 1986-  |e VerfasserIn  |0 (DE-588)104690342X  |0 (DE-627)777295865  |0 (DE-576)398176477  |4 aut 
700 1 |a Schleußner, Nikolai  |e VerfasserIn  |0 (DE-588)1209925583  |0 (DE-627)1697871747  |4 aut 
700 1 |a Schmidt, Thomas  |d 1980-  |e VerfasserIn  |0 (DE-588)132383152  |0 (DE-627)521950023  |0 (DE-576)260799149  |4 aut 
773 0 8 |i Enthalten in  |t International journal of molecular sciences  |d Basel : Molecular Diversity Preservation International, 2000  |g 21(2020,3) Artikel-Nummer 951, 24 Seiten  |h Online-Ressource  |w (DE-627)316340715  |w (DE-600)2019364-6  |w (DE-576)281194653  |x 1422-0067  |7 nnas  |a Oligometastatic gastroesophageal adenocarcinoma molecular pathophysiology and current therapeutic approach 
773 1 8 |g volume:21  |g year:2020  |g number:3  |a Oligometastatic gastroesophageal adenocarcinoma molecular pathophysiology and current therapeutic approach 
856 4 0 |u https://doi.org/10.3390/ijms21030951  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.mdpi.com/1422-0067/21/3/951  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200511 
993 |a Article 
994 |a 2020 
998 |g 132383152  |a Schmidt, Thomas  |m 132383152:Schmidt, Thomas  |d 910000  |d 910200  |d 50000  |e 910000PS132383152  |e 910200PS132383152  |e 50000PS132383152  |k 0/910000/  |k 1/910000/910200/  |k 0/50000/  |p 4  |y j 
998 |g 1209925583  |a Schleußner, Nikolai  |m 1209925583:Schleußner, Nikolai  |d 910000  |d 910200  |e 910000PS1209925583  |e 910200PS1209925583  |k 0/910000/  |k 1/910000/910200/  |p 3 
998 |g 104690342X  |a Nienhüser, Henrik  |m 104690342X:Nienhüser, Henrik  |d 910000  |d 910200  |e 910000PN104690342X  |e 910200PN104690342X  |k 0/910000/  |k 1/910000/910200/  |p 2 
998 |g 1190665913  |a Jung, Jin-On  |m 1190665913:Jung, Jin-On  |d 910000  |d 910200  |e 910000PJ1190665913  |e 910200PJ1190665913  |k 0/910000/  |k 1/910000/910200/  |p 1  |x j 
999 |a KXP-PPN1697871771  |e 3664723171 
BIB |a Y 
SER |a journal 
JSO |a {"recId":"1697871771","id":{"eki":["1697871771"],"doi":["10.3390/ijms21030951"]},"title":[{"title_sort":"Oligometastatic gastroesophageal adenocarcinoma","title":"Oligometastatic gastroesophageal adenocarcinoma","subtitle":"molecular pathophysiology and current therapeutic approach"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 11.05.2020"],"origin":[{"dateIssuedDisp":"31 January 2020","dateIssuedKey":"2020"}],"name":{"displayForm":["Jin-On Jung, Henrik Nienhüser, Nikolai Schleussner and Thomas Schmidt"]},"relHost":[{"id":{"eki":["316340715"],"issn":["1422-0067","1661-6596"],"zdb":["2019364-6"]},"part":{"issue":"3","text":"21(2020,3) Artikel-Nummer 951, 24 Seiten","volume":"21","year":"2020"},"pubHistory":["1.2000 -"],"titleAlt":[{"title":"IJMS"}],"disp":"Oligometastatic gastroesophageal adenocarcinoma molecular pathophysiology and current therapeutic approachInternational journal of molecular sciences","physDesc":[{"extent":"Online-Ressource"}],"recId":"316340715","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 17.09.20"],"title":[{"title":"International journal of molecular sciences","title_sort":"International journal of molecular sciences"}],"origin":[{"publisher":"Molecular Diversity Preservation International","dateIssuedDisp":"2000-","dateIssuedKey":"2000","publisherPlace":"Basel"}]}],"person":[{"family":"Jung","role":"aut","given":"Jin-On","display":"Jung, Jin-On"},{"family":"Nienhüser","role":"aut","given":"Henrik","display":"Nienhüser, Henrik"},{"family":"Schleußner","role":"aut","given":"Nikolai","display":"Schleußner, Nikolai"},{"family":"Schmidt","role":"aut","given":"Thomas","display":"Schmidt, Thomas"}]} 
SRT |a JUNGJINONNOLIGOMETAS3120