Alternative modes of client binding enable functional plasticity of Hsp70: letter
Hsp70 binds unfolded protein segments in its groove, but can also bind and stabilize folded protein structures, owing to its moveable lid, with ATP hydrolysis and co-chaperones allowing control of these contrasting effects.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
26 October 2016
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| In: |
Nature
Year: 2016, Jahrgang: 539, Heft: 7629, Pages: 448-451 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/nature20137 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature20137 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature20137 |
| Verfasserangaben: | Alireza Mashaghi, Sergey Bezrukavnikov, David P. Minde, Anne S. Wentink, Roman Kityk, Beate Zachmann-Brand, Matthias P. Mayer, Günter Kramer, Bernd Bukau & Sander J. Tans |
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