Selective binding and lateral clustering of α5β1 and αvβ3 integrins: unraveling the spatial requirements for cell spreading and focal adhesion assembly

Coordination of the specific functions of α5β1 and αvβ3 integrins is crucial for the precise regulation of cell adhesion, spreading and migration, yet the contribution of differential integrin-specific crosstalk to these processes remains unclear. To determine the specific functions of αvβ3 and α5β1...

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Main Authors: Schaufler, Viktoria (Author) , Czichos-Medda, Helmi (Author) , Hirschfeld-Warneken, Vera C. (Author) , Neubauer, Stefanie (Author) , Rechenmacher, Florian (Author) , Medda, Rebecca (Author) , Kessler, Horst (Author) , Geiger, Benjamin (Author) , Spatz, Joachim P. (Author) , Cavalcanti-Adam, Elisabetta A. (Author)
Format: Article (Journal)
Language:English
Published: 29 Apr 2016
In: Cell adhesion & migration
Year: 2016, Volume: 10, Issue: 5, Pages: 505-515
ISSN:1933-6926
DOI:10.1080/19336918.2016.1163453
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1080/19336918.2016.1163453
Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.1080/19336918.2016.1163453
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Author Notes:Viktoria Schaufler, Helmi Czichos-Medda, Vera Hirschfeld-Warnecken, Stefanie Neubauer, Florian Rechenmacher, Rebecca Medda, Horst Kessler, Benjamin Geiger, Joachim P. Spatz & E. Ada Cavalcanti-Adam
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Summary:Coordination of the specific functions of α5β1 and αvβ3 integrins is crucial for the precise regulation of cell adhesion, spreading and migration, yet the contribution of differential integrin-specific crosstalk to these processes remains unclear. To determine the specific functions of αvβ3 and α5β1 integrins, we used nanoarrays of gold particles presenting immobilized, integrin-selective peptidomimetic ligands.
Item Description:Gesehen am 13.05.2020
Physical Description:Online Resource
ISSN:1933-6926
DOI:10.1080/19336918.2016.1163453