Minichromosome maintenance expression defines slow-growing gastroenteropancreatic neuroendocrine neoplasms

Small intestinal neuroendocrine neoplasm (SI-NEN) proliferation is quantified by Ki67 measurements which capture G1-G2M phases of the cell cycle. G0 and early G1 phases, typical of slow-growing cells, can be detected by minichromosome maintenance protein (MCM) expression. We hypothesized that these...

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Hauptverfasser: Schimmack, Simon (VerfasserIn) , Lawrence, Ben (VerfasserIn) , Kenney, Barton (VerfasserIn) , Schmitz-Winnenthal, Friedrich Hubertus (VerfasserIn) , Modlin, Irvin M. (VerfasserIn) , Kidd, Mark (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 October 2016
In: Translational oncology
Year: 2016, Jahrgang: 9, Heft: 5, Pages: 411-418
ISSN:1936-5233
DOI:10.1016/j.tranon.2016.07.006
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tranon.2016.07.006
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1936523316300626
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Verfasserangaben:Simon Schimmack, Ben Lawrence, Barton Kenney, Hubertus Schmitz-Winnenthal, Irvin M. Modlin and Mark Kidd
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Zusammenfassung:Small intestinal neuroendocrine neoplasm (SI-NEN) proliferation is quantified by Ki67 measurements which capture G1-G2M phases of the cell cycle. G0 and early G1 phases, typical of slow-growing cells, can be detected by minichromosome maintenance protein (MCM) expression. We hypothesized that these replication licensing markers may provide clinically relevant information to augment Ki67 in low-grade neuroendocrine neoplasia.
Beschreibung:Gesehen am 14.05.2020
Beschreibung:Online Resource
ISSN:1936-5233
DOI:10.1016/j.tranon.2016.07.006